Ultrastructure of cortisol-secreting adrenal adenomata

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
C RobbaG G Nussdorfer

Abstract

Two adrenocortical adenomata causing Cushing's syndrome were examined by electron microscopy. Adenomatous cells were arranged in islets and contained ovoid nuclei with a prominent nucleoli. Mitochondria were polymorphic and displayed tubular and lamelliform cristae. Some cells were apparently devoid of lipid droplets and possessed an exceedingly well developed SER, the tubules of which were intermingled with small stacks of ribosome-studded cisternae, while other parenchymal cells contained large clumps of lipid droplets and scanty SER tubules. A conspicuous Golgi apparatus and many dense bodies of probable lysosomal nature were also observed. These findings suggest that the adenomata are derived from the zona fasciculata and that lipid-laden and lipid-free cells are, respectively, resting and actively secreting elements.

References

Jun 3, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·K Kano, S Sato
Jan 1, 1979·Virchows Archiv. A, Pathological Anatomy and Histology·K I KanoH Hama
Dec 1, 1976·Beiträge Zur Pathologie·K GorgasS Wuketich
Nov 30, 1977·Cell and Tissue Research·O KaiM Yasuda
Apr 17, 1978·Virchows Archiv. A, Pathological Anatomy and Histology·H MitschkeH J Breustedt
Jan 1, 1978·International Review of Cytology·G G NussdorferV Meneghelli
Aug 1, 1970·The Journal of Cell Biology·D S Friend, G E Brassil
Jan 1, 1971·Zeitschrift für Zellforschung und mikroskopische Anatomie·G NussdorferL Rebonato
Nov 1, 1973·The British Journal of Ophthalmology·F A JakobiecM Tannenbaum
Mar 15, 1974·Biochemical and Biophysical Research Communications·H P WangT T Tchen
Jan 1, 1969·The Journal of Endocrinology·N DeshpandeT W Doouss
May 1, 1969·Acta Pathologica Japonica·A Kawaoi
May 1, 1969·Journal of Ultrastructure Research·M Hoshino
Nov 1, 1965·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I Lasnitzki
Dec 1, 1961·The Journal of Biophysical and Biochemical Cytology·M J KARNOVSKY
Jan 1, 1980·International Review of Cytology·G G Nussdorfer

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