Ultrastructure of enterochromaffin-like cells in rat stomach: effects of alpha-fluoromethylhistidine-evoked histamine depletion and hypergastrinemia

Cell and Tissue Research
D ChenR Håkanson

Abstract

Histamine-producing enterochromaffin-like (ECL) cells are numerous in the oxyntic mucosa of the rat stomach. They respond to gastrin by secretory activation, hypertrophy and hyperplasia. They contain cytoplasmic granules (median profile diameter 120 nm), secretory vesicles (180 nm) and microvesicles (70 nm). alpha-Fluoromethylhistidine (alpha-FMH) depletes histamine from the ECL cells by inhibiting the histamine-forming enzyme histidine decarboxylase. Long-term hypergastrinemia, evoked by omeprazole, increases the ECL-cell histamine concentration. The way in which chronic histamine depletion affects omeprazole-induced ECL-cell hypertrophy, and the ways in which granules and vesicles in the ECL cells respond to alpha-FMH and/or omeprazole have been studied. Rats were treated with alpha-FMH (3 mg/kg per h subcutaneously), omeprazole (400 micromol/kg per day orally), alpha-FMH+omeprazole, or vehicle for 6 weeks. ECL cell profiles in electron micrographs were analysed panimetrically. The results show that the omeprazole-evoked hypertrophy of the ECL cells is not affected by depletion of ECL-cell histamine, thereby supporting the view that ECL-cell histamine is not important for full expression of the gastrin-evoked trophic effects ...Continue Reading

Citations

May 21, 2005·Cell and Tissue Research·Lennart Friis-HansenFrank Sundler
Jun 22, 2012·Medical Molecular Morphology·Reidar Alexander VigenChun-Mei Zhao
Jan 14, 2000·European Journal of Pharmacology·E LindströmR Håkanson
May 14, 1999·General Pharmacology·D ChenR Håkanson
Apr 12, 2003·Pharmacology & Toxicology·Duan ChenJens F Rehfeld
Jul 6, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Reidar FossmarkHelge L Waldum
Mar 4, 2000·Microscopy Research and Technique·C BordiG Ferraro
Jul 24, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eiji NakamuraSusumu Okabe
Nov 24, 1999·The American Journal of Physiology·C PrinzM Gratzl

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