PMID: 6980689Jun 3, 1982Paper

Ultrastructure of frog cerebral and pial microvessels and their impermeability to lanthanum ions

Brain Research
M Bundgaard

Abstract

Permeabilities of single pial microvessels in the frog are now being estimated. Fine structural information on these vessels will therefore be needed in attempts to correlate structure and permeability. Microvessels from the dorsal part of the telencephalon and from the overlying pial layer in the common frog (Rana temporaria) and their permeability to lanthanum ions were studied in the electron microscope. Extensive structural similarities between the endothelial lining of cerebral and pial microvessels were demonstrated, indicating similarity in functional characteristics. Adjacent endothelial cells in both categories of vessels were joined by elaborate tight junctions. Lanthanum ions did not permeate the endothelium. Diffusion of the ion in the interendothelial clefts was stopped by the junctions. It is concluded that the frog has an endothelial blood-brain barrier which is tight to lanthanum ions.

References

Oct 1, 1978·The Journal of Cell Biology·N SimionescuG E Palade
Nov 15, 1975·The Journal of Comparative Neurology·S NabeshimaM W Brightman
May 1, 1976·Journal of Neurobiology·J Perez-GomezE M Wright
Jan 1, 1974·Tissue & Cell·T P Kenny, R R Shivers
Mar 1, 1968·The American Journal of Anatomy·T S Bodenheimer, M W Brightman
Mar 1, 1969·The Journal of Cell Biology·M W Brightman, T S Reese
Sep 1, 1969·The Journal of Cell Biology·G MajnoM Leventhal
Jun 3, 1982·Brain Research·C Crone, S P Olesen
Dec 7, 1981·Brain Research·M Bundgaard, H Cserr
Jan 1, 1980·Microvascular Research·J FoxH Wayland
Dec 1, 1961·The Journal of Biophysical and Biochemical Cytology·G MAJNOG I SCHOEFL

❮ Previous
Next ❯

Citations

Jan 1, 1985·Acta Neuropathologica·Y NakagawaJ Artigas
Apr 1, 1992·Journal of Neurocytology·N J Abbott, M Bundgaard
May 7, 1984·Brain Research·M E MichelS I Rapoport
Dec 24, 1995·Brain Research·E SanovichM W Brightman
Mar 18, 1994·Brain Research. Developmental Brain Research·P A Stewart, K Hayakawa
Jan 1, 1987·Progress in Neurobiology·E Rechthand, S I Rapoport
Jun 1, 1997·Brain Research. Brain Research Reviews·G Allt, J G Lawrenson
Jan 6, 2000·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·H DownesN Lessov
Jan 15, 1987·Nature·N J Abbott
Dec 1, 1991·The Journal of Cell Biology·L L RubinJ Morales
Apr 13, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Takayuki KatoKeiji Kawamoto
Jun 1, 1986·Acta Physiologica Scandinavica·S P Olesen, C Crone
May 1, 1987·Acta Physiologica Scandinavica·S P Olesen
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·S DuportL Stoppini
Jun 3, 1982·Brain Research·C Crone, S P Olesen
Jun 4, 1986·Brain Research·A Weerasuriya, S I Rapoport
Mar 1, 2012·Neurotoxicology·Evelyn Tiffany-Castiglioni, Yongchang Qian
Jan 1, 1986·Annals of the New York Academy of Sciences·C Crone
Jan 1, 1986·Annals of the New York Academy of Sciences·M Bundgaard
Sep 1, 1984·Microvascular Research·M E MichelS I Rapoport
Aug 1, 1985·Circulation Research·M W Bradbury
Jan 1, 1990·Eye·M W Bradbury, S L Lightman
Jan 7, 2005·Journal of Neuroscience Research·Shujun GeJoel S Pachter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.