Ultrastructure of human parathyroid cells in health and disease

Microscopy Research and Technique
S Cinti, A Sbarbati

Abstract

Parathyroid glands (n = 271) removed from 130 patients were examined by light and electron microscopy. A standardized method of tissue processing was employed and morphometry was performed. The aim of the paper is to provide a description of the human parathyroid chief cell ultrastructure in health and disease, with quantitative evaluation of structures involved in secretion of parathyroid hormone in a large case series, and to discuss their role in current diagnostic histopathology. The patients were euparathyroid (n = 10), or affected by primary (n = 97), secondary (n = 8), or tertiary (n = 15) hyperparathyroidism. In normal glands, solid parenchyma was composed of chief cells, large clear cells, transitional-oxyphil cells, and oxyphil cells. Chief cell hyperplasia, pseudo-adenomatous hyperplasia, adenoma, water-clear cell hyperplasia, and carcinoma were the most usual forms of parathyroid disease responsible for primary hyperparathyroidism. In chief cell hyperplasia, all the parathyroid glands were enlarged and the chief cells were in an active state of hormone secretion, with a large Golgi complex, abundant rough endoplasmic reticulum (RER), small lipid droplets, and tortuous plasma membrane. In pseudo-adenomatous hyperplas...Continue Reading

References

Oct 1, 1979·American Journal of Surgery·G L Irvin, C B Bagwell
Jul 1, 1978·Journal of Clinical Pathology·D A Lawrence
Nov 11, 1975·Human Pathology·S I RothJ T Potts
Mar 1, 1976·Human Pathology·S Kay
Jun 1, 1989·The American Journal of Surgical Pathology·H R WolpertC A Wang
Jan 1, 1985·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H O LarssonL Boquist
Jan 1, 1987·Histochemistry·P WildE M Schraner
Jan 1, 1985·Cell and Tissue Research·P Wild, E M Manser
Aug 1, 1985·Human Pathology·M W Krause, C E Hedinger
Feb 1, 1973·The Surgical Clinics of North America·E PaloyanJ R Pickleman
May 1, 1971·The American Journal of Medicine·S I Roth
Jan 1, 1970·Annals of Surgery·R C HaffW F Ballinger
May 1, 1970·American Journal of Clinical Pathology·W C Black, R C Haff
Jun 1, 1968·American Journal of Clinical Pathology·W C Black, J R Utley
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·K NakagamiY Tsunoda
Oct 1, 1969·Archives of Internal Medicine·S I Roth, R B Marshall
Dec 1, 1966·Acta Endocrinologica·R J Weymouth, M N Sheridan
Oct 1, 1967·American Journal of Surgery·M A BlockB Frame
Jun 1, 1981·The American Journal of Surgical Pathology·E J KasdonW Silen
Mar 1, 1982·The American Journal of Surgical Pathology·K T Chen
Aug 1, 1982·Human Pathology·D R Dufour, S Y Wilkerson
Jan 25, 1958·The Journal of Biophysical and Biochemical Cytology·J S TRIER
Jan 1, 1962·Virchows Archiv Für Pathologische Anatomie Und Physiologie Und Für Klinische Medizin·S I ROTH, B L MUNGER

❮ Previous
Next ❯

Citations

May 29, 2012·Endocrine Pathology·Shuting BaiZhanyong Bing
Feb 11, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yuhong ShiJohn A Olson
Sep 14, 2011·World Journal of Surgery·Carlos Eduardo Santa Ritta BarreiraFábio Luiz de Menezes Montenegro
Dec 1, 2014·Surgical Pathology Clinics·Virginia A LiVolsiZubair N Baloch
Sep 20, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nobuo NaganoMichihito Wada
Feb 11, 1999·The Anatomical Record·J I Haynes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.