PMID: 11934602Apr 6, 2002Paper

Ultrastructure of intramural coronary arteries in pigs with hypertrophic cardiomyopathy

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Jeou-Jong ShyuSi-Kwang Liu

Abstract

Pigs with hypertrophic cardiomyopathy diagnosed by echocardiographic examination were selected for study from a genetic breeding herd. Under dissecting microscopic examination, intramural coronary arteries in the septum and left ventricular free wall of euthanized pigs were collected for ultrastructural study. The major lesions of wall thickening included degeneration or denudation of endothelium, subendothelial edema, proliferation of collagen fiber, and hyperplasia of smooth muscle cells. Smooth muscle cells proliferated and migrated through the internal elastic lamella into the intima, which caused the early lesion of wall thickening of the intramural coronary arteries. The extent of smooth muscle cell proliferation was related to the severity of endothelial damage. The smooth muscle cells in the intima were identified by immunohistochemical staining (i.e., smooth muscle actin [SMA] stain). Three major types of severe wall thickening with narrow lumen were observed in the intramural coronary arteries. Edema in the intima caused the major lesion of Type I wall thickening. The internal elastic lamella was broken into small interrupted fragments, and fine fragments of elastic fibers surrounded by the cellular processes of smoot...Continue Reading

References

Dec 1, 1979·Virchows Archiv. A, Pathological Anatomy and Histology·K KoboriG Ooneda
Jun 1, 1979·The American Journal of Cardiology·B J Maron, S E Epstein
Nov 11, 1992·Journal of the American College of Cardiology·R S SchwartzE J Topol
Dec 1, 1992·Hypertension·C L Jackson, S M Schwartz
Apr 15, 1989·The American Journal of Cardiology·J J GlazierD P Faxon
Apr 1, 1988·Journal of the American College of Cardiology·A J BlackS B King
Sep 1, 1986·Journal of the American College of Cardiology·B J MaronW C Roberts
Aug 1, 1981·The Journal of Cell Biology·J J CastellotM J Karnovsky
Oct 1, 1994·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·S K LiuP C Yang

❮ Previous
Next ❯

Citations

Nov 26, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Zanxin WangAri Mennander
Apr 22, 2011·American Journal of Hypertension·Francesco BartolomucciCarlo Palombo
Oct 30, 2018·Pflügers Archiv : European journal of physiology·Richard J MarszalekBeata M Wolska
Jan 8, 2021·Frontiers in Veterinary Science·Marie-Pierre Ryser-DegiorgisFrancesco C Origgi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.