Ultrastructure of invasion in different tissue types by Lewis lung tumour variants

Virchows Archiv. A, Pathological Anatomy and Histopathology
Sándor PakuK Lapis

Abstract

Ultrastructural studies on the interactions of low and highly metastatic 3LL tumour lines with the basement membranes (BMs) of capillaries, veins, muscles, nerves and adipose tissue were performed by injecting tumour cells into the foot pad of mice. Haematogenous dissemination is the principle route of metastasis formation. Cells from the highly metastatic line were able to penetrate the blood vessels more efficiently than those from the low metastatic line. This difference was mainly due to a more pronounced diapedesis-like activity of the 3LL-HH cells, and partly to the altered intratumour vessel architecture in the highly metastatic tumour line. There was no difference between the two lines in the ultrastructure and frequency of invasion of nerves and adipose tissue BMs. However, in the highly metastatic line an extremely efficient penetration of muscle cell BM was observed. These results provide further evidence that the interaction of tumour cells with the BMs of different tissue types is one of the main determinants in local and distant dissemination.

References

Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·P ConstantinidesM Harkey
Nov 25, 1987·Biochimica Et Biophysica Acta·K TryggvasonT Salo
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H GabbertJ Bohl
Nov 1, 1988·Pathology, Research and Practice·K P Dingemans
Jan 1, 1988·Experimental Cell Biology·J N KitinyaK Tanaka
Jan 1, 1986·Tissue & Cell·M J SongM Hussain
Jan 1, 1974·British Journal of Cancer·C S Galasko, D S Muckle
Jan 1, 1984·Cancer Metastasis Reviews·B F Sloane, K V Honn

❮ Previous
Next ❯

Citations

Apr 29, 1998·Pathology Oncology Research : POR·S Paku
Dec 2, 2005·Clinical & Experimental Metastasis·Masuo HanadaYukihide Iwamoto
Apr 6, 2012·Clinical & Experimental Metastasis·Gert G Van den EyndenPeter B Vermeulen
Mar 1, 2019·Journal of Neuropathology and Experimental Neurology·Vanda TéglásiLilla Reiniger
Mar 1, 2005·Radiology·Pari V PandharipandeVivian S Lee
May 29, 1997·International Journal of Cancer. Journal International Du Cancer·J TóváriJ Tímár

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved