Ultrastructure of Kupffer cells and hepatocytes in the Dubin-Johnson syndrome: a case report

World Journal of Gastroenterology : WJG
Maria Elzbieta Sobaniec-Lotowska, Dariusz Marek Lebensztejn

Abstract

Ultrastructure of Kupffer cells and hepatocytes in liver bioptate was evaluated in a 17-year-old boy with Dubin-Johnson syndrome (DJS). The liver tissue obtained by needle biopsy was fixed in glutaraldehyde and paraformaldehyde and routinely processed for electron microscopic analysis. The ultrastructural examinations of liver bioptate revealed the accumulation of membrane-bound, electron-dense lysosomal granules within the cytoplasm of hepatocytes, characteristic of DJS. They were located mainly in the vicinity of the biliary pole, and preferentially in the centrilobular region that corresponded to the pigment deposits seen under light microscope. The presence of the granules was accompanied by dilated elements of the granular endoplasmic reticulum and paracrystalline mitochondrial inclusions as well as dilation of the bile canaliculi. The changes in hepatocytes co-existed with marked stimulation and enhanced phagocytic activity of Kupffer cells. This was manifested in the accumulation of pigment deposits within their cytoplasm that corresponded to those observed in hepatocytes. Hyperactive pericentral Kupffer cells which are involved in the response to pigmentary material originating from disintegrated hepatocytes may play an...Continue Reading

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Citations

Jul 23, 2009·European Journal of Gastroenterology & Hepatology·Joanna M LotowskaDariusz M Lebensztejn
Oct 16, 2012·Annals of Clinical Biochemistry·Manjit S DevgunRaoul Poupon
Nov 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Florian GeltingerMark Rinnerthaler
Sep 11, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Padmarajaiah NagarajaAshwinee Kumar Shrestha

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