Ultrastructure of myopericytoma: a continuum of transitional phenotypes of myopericytes

Ultrastructural Pathology
Lucio Díaz-FloresJuan F Madrid

Abstract

The authors report the ultrastructural characteristics of myopericytoma, a recently described variant of perivascular (pericytic) tumors, mainly with regard to their myopericytic cells and vessels. Myopericytes range between pericytes and vascular smooth muscle cells (SMCs) in a morphologic continuum. The principal findings of the intermediate phenotypes are (1) elongated or annular morphology with processes of varying length and thickness (usually long and thin); (2) a continuous, irregularly thickened and zonally duplicated basement membrane; (3) heterocellular "peg and socket" junctions with neighboring endothelial cells, and scarce specialized junctions between myopericytes; (4) numerous micropinocytotic vesicles, whether continuous or forming focal rows; (5) abundant thin microfilaments, grouped in bundles with dense bodies and adhesion plaques; (6) poorly developed synthetic system (RER and Golgi); (7) pseudointracellular bodies formed by invagination of basement and plasma membranes, with numerous endocytic vesicles; and (8) zones of cytoplasmic rarefaction near micropinocytotic vesicles and intracellular organelles. The ultrastructure of myopericytes therefore makes it possible to distinguish them from pericytes, SMCs, ...Continue Reading

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Citations

Jul 27, 2014·Journal of the National Cancer Institute·Peter M SadowCarmelo Nucera
Oct 29, 2014·Case Reports in Orthopedics·Adnan KaraMurat Bülbül
Dec 23, 2015·Ultrastructural Pathology·Lucio Díaz-FloresLucio Díaz-Flores
Nov 1, 2020·International Journal of Molecular Sciences·Lucio Díaz-FloresJuan Francisco Madrid

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