Ultrastructure of the adrenal medulla of normal and insulin-treated hamsters.

Cell and Tissue Research
I Benedeczky, P Somogyi

Abstract

Fine structural characteristics of the chromaffin cells both in normal and insulin-administered hamster adrenal gland were studied. Exocytosis occurs in 5 per cent of nonstimulated cells especially on the apical cell surfaces. At the same time the occurrence of a great number of closely attached secretory granules was conspicuous on the lateral plasma membrane in the untreated hamster adrenal medulla. Following insulin treatment (10 IU/100 g/body weight), characteristic was the development of large intercellular vacuoles between the lateral plasma membrane, in which electron-dense secretory material was frequently present. On the basis of this observation it is suggested that in the case of insulin-induced hormone secretion, exocytosis preferentially occurs on the lateral plasma membrane, and may play an important role in the discharge of secretory materials from the cells.

Citations

Jan 1, 1978·The Journal of Cell Biology·E M FenwickB G Livett
Sep 26, 2006·Advanced Drug Delivery Reviews·Haruo KasaiNoriko Takahashi
Feb 10, 2006·The EMBO Journal·Takuya KishimotoHaruo Kasai

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