Ultrastructure of the mineralizing metacarpophalangeal joint of progressive ankylosis (ank/ank) mice

The American Journal of Anatomy
H W Sampson

Abstract

The metacarpophalangeal joint of the progressive ankylosis mouse was examined at 4, 6 and 8 weeks of age by using electron microscopy and electron probe microanalysis. These studies describe the progression of the disorder, and they reveal three overlapping phases: pannus proliferation, chondrophyte formation and mineralization, and articular cartilage mineralization. The chondrophyte mineralized in a manner fairly similar to endochondrial bone, whereas articular cartilage mineralized by advancement of a calcification front across the cartilage. Synovial crystal phagocytosis was also observed. The progressive ankylosis mouse should be an important model for studying both crystal deposition and abnormal articular cartilage calcification.

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Citations

Dec 17, 2004·Molecular and Cellular Biology·Wei WangThorsten Kirsch
May 15, 2003·Current Rheumatology Reports·H Clarke Anderson
May 19, 2009·American Journal of Medical Genetics. Part a·Gareth BaynamLyn Schofield
Jul 1, 1990·Bone and Mineral·H W Sampson, J P Trzeciakowski
Dec 23, 2006·American Journal of Human Genetics·Kyle A GurleyDavid M Kingsley

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