PMID: 4933472Jun 1, 1971Paper

Ultrastructure of the nucleolus during the Chinese hamster cell cycle

The Journal of Cell Biology
J S NoelR P Thompson


Changes in the structure of the nucleolus during the cell cycle of the Chinese hamster cell in vitro were studied. Quantitative electron microscopic techniques were used to establish the size and volume changes in nucleolar structures. In mitosis, nucleolar remnants, "persistent nucleoli," consisting predominantly of ribosome-like granular material, and a granular coating on the chromosomes were observed. Persistent nucleoli were also observed in some daughter nuclei as they were leaving telophase and entering G(1). During very early G(1), a dense, fibrous material characteristic of interphase nucleoli was noted in the nucleoplasm of the cells. As the cells progressed through G(1), a granular component appeared which was intimately associated with the fibrous material. By the middle of G(1), complete, mature nucleoli were present. The nucleolar volume enlarged by a factor of two from the beginning of G(1) to the middle of S primarily due to the accumulation of the granular component. During the G(2) period, there was a dissolution or breakdown of the nucleolus prior to the entry of the cells into mitosis. Correlations between the quantitative aspects of this study and biochemical and cytochemical data available in the literatur...Continue Reading


Jan 1, 1969·The Journal of Cell Biology·S G Phillips, D M Phillips
Aug 1, 1965·The Journal of Cell Biology·T C HsuB R Brinkley
Mar 1, 1969·The Journal of Cell Biology·A Lord, J G LAFONTAINE
Jan 1, 1967·Zeitschrift für Zellforschung und mikroskopische Anatomie·B von Gaudecker
May 23, 1969·Science·O L Miller, B R Beatty
Jul 1, 1969·The Journal of Cell Biology·M C Liau, R P Perry
Jun 1, 1965·Journal of Ultrastructure Research·B B HydeM L Birnstiel
Aug 1, 1965·The Journal of Cell Biology·R G MurrayA Pizzo
Nov 1, 1965·The Journal of Cell Biology·J A Terzakis
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·J H LUFT
Oct 7, 1960·Annals of the New York Academy of Sciences·J H TAYLOR
Apr 1, 1963·The Journal of Cell Biology·J G LAFONTAINE, L A CHOUINARD
Oct 1, 1962·Journal of Ultrastructure Research·O P JONES
Feb 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·M GIRARDJ E DARNELL
Apr 1, 1964·Journal of Ultrastructure Research·G I SCHOEFL
Jun 1, 1964·The Journal of Cell Biology·E ROBBINS, N K GONATAS
Feb 1, 1965·Journal of Molecular Biology·M GIRARDJ E DARNELL
Mar 1, 1962·Experimental Cell Research·D M PRESCOTT, M A BENDER
Mar 1, 1952·The Journal of Experimental Medicine·G E PALADE


Feb 1, 1972·Journal of Morphology·F B Adamstone, A B Taylor
Jan 1, 1983·Human Genetics·H G Schwarzacher, F Wachtler
Jan 1, 1985·Chromosoma·R L OchsH Busch
May 1, 1980·Journal of Ultrastructure Research·P Goldstein, A C Triantaphyllou
Oct 1, 1973·The Journal of Cell Biology·T SimmonsL Hodge
Jan 1, 1974·The Journal of Cell Biology·A L Kierszenbaum, L L Tres
Mar 1, 1983·The Journal of Cell Biology·D G Capco, S PENMAN
Mar 1, 1976·European Journal of Biochemistry·L Hall, G Turnock
Mar 1, 1977·Australasian Radiology·E Papadopoulos, R W Stanford
Aug 1, 1972·Biological Reviews of the Cambridge Philosophical Society·N Maclean, R D Jurd
Sep 1, 1995·The Journal of Eukaryotic Microbiology·J A DvorakC W Hallahan
Oct 13, 2001·The Journal of Eukaryotic Microbiology·J D Berger
Mar 1, 1997·Photochemistry and Photobiology·K Berg, J Moan
Jun 1, 1979·Journal of Cellular Physiology·A M Mastro
Aug 1, 1978·Journal of Cellular Physiology·C R Jones, J R Cook
May 1, 1994·Journal of Neuroscience Research·Y MullerJ Clos
Jan 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sara C Kozma, George Thomas
Jan 1, 1972·Zeitschrift für allgemeine Mikrobiologie·E Streiblová, A Wolf
Jan 1, 1976·Zeitschrift für allgemeine Mikrobiologie·C S Penman, J H Duffus
Dec 20, 1989·Biotechnology and Bioengineering·E Suzuki, D F Ollis
Feb 1, 1978·The Journal of Experimental Zoology·F J Longo
Jan 1, 1985·Chronobiology International·R Seite, M J Pébusque
Feb 1, 1982·Experimental Cell Research·A Lepoint, G Goessens
Nov 1, 1982·Journal of Ultrastructure Research·C A BourgeoisM Bouteille
Feb 1, 1976·Journal of Ultrastructure Research·P Kellokumpu-LehtinenP Tuohimaa
Apr 1, 1974·Journal of Ultrastructure Research·F Palombi, M Stefanini
Nov 1, 1979·Journal of Ultrastructure Research·D Hernandez-Verdun, M Bouteille
Mar 1, 1972·Experimental Cell Research·R J RoseL C Fowke
Apr 1, 1974·Differentiation; Research in Biological Diversity·G C KarpW E Hahn
Oct 7, 2004·International Review of Cytology·Patrick J Dimario
Jul 1, 2020·Annual Review of Cell and Developmental Biology·Wallace F Marshall

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