PMID: 16633224Apr 25, 2006Paper

Ultrastructure of the trabecular meshwork in secondary glaucoma eyes after intravitreal triamcinolone acetonide

Journal of Glaucoma
Toshiaki KubotaAkihiko Tawara

Abstract

To study the histology of the trabecular meshwork of eyes with glaucoma by intravitreal injection of triamcinolone acetonide (TA). Two cases report. A 68-year-old Japanese man with branch retinal vein occlusion and a 48-year-old Japanese woman with uveitis were treated by cataract surgery, intraocular lens implantation, and TA-assisted pars plana vitrectomy. At the end of surgery, TA suspension (4 mg) was intravitreously injected. During the follow-up period, the intraocular pressure (IOP) of the patients increased over 30 mm Hg even with full medication. Trabeculectomy was performed at 4 months after TA injection in case 1 and at 6 months in case 2, and intraocular pressure returned to the normal range in both cases. Light and electron microscopic studies of the resected trabecular tissue were carried out. The histology showed minimal deposition of extracellular matrix in the trabecular meshwork in case 1. Case 2 showed the beginnings of deposition of extracellular matrix including fingerprintlike material in the trabecular meshwork with decreased intertrabecular spaces. The ultrastructural changes in the trabecular meshwork of eyes with glaucoma after treatment with intravitreal TA might resemble those with glaucoma after top...Continue Reading

References

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Citations

Apr 22, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sophie J BakriDarius M Moshfeghi
May 26, 2011·International Ophthalmology·Eleni LoukianouMichael Apostolopoulos
Nov 28, 2007·Retina·Iryna A FalkensteinWilliam R Freeman
Nov 21, 2009·The Journal of Pharmacology and Experimental Therapeutics·Rajendra S Kadam, Uday B Kompella
Aug 20, 2014·Ophthalmology and Therapy·Ehab M Ghoneim, Ahmed A Abd El Ghany
Apr 18, 2009·Seminars in Ophthalmology·Huijuan Wu, Teresa C Chen
Jun 19, 2013·Survey of Ophthalmology·Weerawat KiddeeYvonne M Buys
Mar 4, 2011·Journal français d'ophtalmologie·N PogorzalekM Labetoulle
Oct 17, 2009·Survey of Ophthalmology·Sarwat Salim, M Bruce Shields
Jul 15, 2009·Clinical & Experimental Ophthalmology·Saskia M MacaTalin Barisani-Asenbauer
Jun 24, 2015·Journal français d'ophtalmologie·C DotE Agard
Mar 15, 2011·American Journal of Ophthalmology·Keiichiro IwaoUNKNOWN Japanese Steroid-Induced Glaucoma Multicenter Study Group
Mar 2, 2016·Experimental Eye Research·Tomokazu FujimotoHidenobu Tanihara
Jul 16, 2011·Ophthalmic Research·M Reza Razeghinejad, L Jay Katz
Jun 1, 2008·Clinical Ophthalmology·Pier E Gallenga, Lucio Lobefalo
Jul 6, 2021·European Journal of Ophthalmology·Elvan Kucukkomurcu, Tayfun Sahin

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