Ultrathin coating by plasma polymerization applied to corneal contact lens.

Journal of Biomedical Materials Research
H YasudaJ Carver

Abstract

Plasma coating (deposition of polymer under the influence of plasma) is utilized to modify the surface properties of corneal contact lens. An ultrathin layer (thickness of roughly 200 A) of plasma polymer of acetylene/H20/N2 is applied to poly(methyl methacrylate) (PMMA) corneal contact lenses. The surface becomes highly wettable with water compared to uncoated lens. When coated and uncoated contact lenses are placed on rabbit eyes, a remarkable difference in accumulation of mucous matter is observed. With the control lenses, the accumulation of mucous matter in a week is sufficient to affect the optical clarity of the lenses, whereas the coated lenses show no change after three months continuous wearing. The comparative degree of adhesion of the corneal epithelium cells onto glass, modified glass, PMMA, and coated PMMA surfaces is studied using tissue cultures and phase contrast microscopy. The coated PMMA surface exhibits a degree of tissue adhesion lower than that of control PMMA and higher than that of glass surface, and no sign of toxicity of the coated surface is observed by the tissue cultures.

Citations

Mar 1, 1979·Journal of Biomedical Materials Research·M F NicholsK G Mayhan
Aug 26, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Andrew MichelmoreRobert D Short
Dec 25, 2015·ACS Applied Materials & Interfaces·Thierry MoserDrew R Evans
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Melissa BarnettPhilip B Morgan
Sep 1, 1978·Journal of Biomedical Materials Research·H YasudaD P Devito
May 1, 1980·Journal of Biomedical Materials Research·J G CannonA M Dymond

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