Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

Nature Medicine
Michelle AszterbaumErvin H Epstein

Abstract

Basal cell carcinomas, the commonest human skin cancers, consistently have abnormalities of the hedgehog signaling pathway and often have PTCH gene mutations. We report here that Ptch+/- mice develop primordial follicular neoplasms resembling human trichoblastomas, and that exposure to ultraviolet radiation or ionizing radiation results in an increase in the number and size of these tumors and a shift in their histologic features so that they more closely resemble human basal cell carcinoma. The mouse basal cell carcinomas and trichoblastoma-like tumors resemble human basal cell carcinomas in their loss of normal hemidesmosomal components, presence of p53 mutations, frequent loss of the normal remaining Ptch allele, and activation of hedgehog target gene transcription. The Ptch mutant mice provide the first mouse model, to our knowledge, of ultraviolet and ionizing radiation-induced basal cell carcinoma-like tumors, and also demonstrate that Ptch inactivation and hedgehog target gene activation are essential for basal cell carcinoma tumorigenesis.

References

Feb 1, 1992·The British Journal of Dermatology·A C MarkeyI M Leigh
Mar 1, 1987·Medicine·R J Gorlin
Nov 1, 1972·The Journal of Investigative Dermatology·K HashimotoR Bernhard
Jul 1, 1994·The British Journal of Dermatology·B R SmollerR A Warnke
Mar 1, 1994·The Journal of Investigative Dermatology·Anthony G QuinnJ L Rees
May 1, 1994·Journal of the American Academy of Dermatology·D L Miller, M A Weinstock
Sep 1, 1995·The British Journal of Dermatology·J A FairleyG J Giudice
Mar 20, 1996·Journal of the National Cancer Institute·M R GailaniAllen E Bale
Dec 18, 1996·Journal of the National Cancer Institute·Margaret R KaragasM M Stevens
May 2, 1997·Science·Anthony E OroM P Scott

Citations

Jan 20, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·S Völter-MahlknechtW Wehrmann
Dec 7, 2007·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J Hatina, T Ruzicka
Nov 27, 2004·Archives of Dermatological Research·Miki TaniokaTadahiko Iizuka
Jan 29, 2010·Journal of Bone and Mineral Metabolism·Daniel D Bikle
Nov 28, 2012·Cancer Metastasis Reviews·Michael D GoberJohn T Seykora
Jul 12, 2007·Journal of Mammary Gland Biology and Neoplasia·Sarah Hatsell, Andra R Frost
Aug 17, 2011·Reviews in Endocrine & Metabolic Disorders·Daniel D Bikle
Jul 28, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M Pons, M Quintanilla
Apr 22, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Vanessa MedinaJesús Espada
Jun 1, 2005·Cancer Letters·Simonetta Pazzaglia
Jun 9, 2004·International Journal of Oral and Maxillofacial Surgery·S-G AhnJ-H Yoon
Mar 22, 2003·Developmental Biology·Anthony E Oro, Kay Higgins
Nov 5, 2003·Developmental Biology·Tammy EllisBrandon Wainwright
Aug 2, 2003·Cancer Letters·A ZafiropoulosD A Spandidos
Mar 12, 2004·Cancer Letters·Ariel Ruiz i AltabaPilar Sánchez
May 22, 2002·Biochimica Et Biophysica Acta·Michaela Herzig, Gerhard Christofori
Nov 8, 2001·Current Opinion in Cell Biology·B Hann, Allan Balmain
Sep 5, 2001·Current Opinion in Genetics & Development·C A Callahan, Anthony E Oro
Feb 8, 2003·Current Opinion in Genetics & Development·Cynthia Wetmore
Dec 24, 2002·Trends in Cell Biology·José L MullorAriel Ruiz i Altaba
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·Frank R de GruijlL H Mullenders
Sep 17, 2002·Methods : a Companion to Methods in Enzymology·Stefan Beissert
Mar 4, 2000·Nature Genetics·M GrachtchoukAndrzej A Dlugosz
Sep 25, 2008·Nature Reviews. Cancer·Ervin H Epstein
Dec 2, 2006·Nature Reviews. Drug Discovery·Lee L Rubin, F J De Sauvage
Sep 21, 2012·The Journal of Biological Chemistry·Dongsheng GuJingwu Xie
Mar 17, 2004·The Journal of Experimental Medicine·Annika VogtErvin H Epstein
Nov 21, 2000·Human Gene Therapy·P A Khavari
May 8, 2004·Antioxidants & Redox Signaling·C NishigoriShinya Toyokuni
Jul 29, 2008·Carcinogenesis·Mirella TanoriAnna Saran
Mar 4, 2000·The American Journal of Dermatopathology·P E LeBoit
Apr 4, 2001·The American Journal of Dermatopathology·R BöniG Burg
Apr 30, 2002·The American Journal of Dermatopathology·Noriyuki Misago, Yutaka Narisawa
May 31, 2003·The American Journal of Dermatopathology·P E LeBoit
Jul 14, 2004·The American Journal of Dermatopathology·Noriyuki MisagoYutaka Narisawa
Mar 31, 2005·The American Journal of Dermatopathology·Anneli R Bowen, P E LeBoit
May 24, 2007·The American Journal of Dermatopathology·Noriyuki MisagoYutaka Narisawa
Jan 25, 2005·Clinical and Experimental Dermatology·John T LearAnthony A Fryer
Jun 6, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jeff Donovan
Jun 17, 2010·Photochemistry and Photobiology·Clio DessiniotiAlexander J Stratigos
Jun 16, 2010·Pigment Cell & Melanoma Research·Neil F BoxDennis R Roop
Apr 3, 2001·Annual Review of Neuroscience·R Wechsler-Reya, M P Scott
May 12, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tracy TangF J De Sauvage
Mar 26, 2011·Cancer Prevention Research·Jean Y TangErvin H Epstein
Apr 7, 2004·The Journal of Clinical Investigation·Xiuwei TangMohammad Athar
Dec 7, 2007·The Journal of Clinical Investigation·Wafik S El-Deiry
Apr 27, 2011·The Journal of Clinical Investigation·Marina GrachtchoukAndrzej A Dlugosz
Feb 2, 2012·The Journal of Clinical Investigation·Maria KasperRune Toftgard
Feb 2, 2012·The Journal of Clinical Investigation·John R Stanley
Jan 11, 2013·International Journal of Molecular Sciences·Joanna SzkanderaMartin Pichler
Sep 3, 2013·Journal of Visualized Experiments : JoVE·Dongsheng GuJingwu Xie
Jan 5, 2011·Chinese Journal of Cancer·Hailan LiuJingwu Xie
Jun 1, 2014·Archives of Pathology & Laboratory Medicine·Stefan Kraft, Scott R Granter
Sep 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Julie B SneddonPatrick O Brown
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·J XieF McCormick
Sep 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jennifer J TrowbridgeMickie Bhatia
Apr 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Juliet A WilliamsFrank Y Wang
Jan 16, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Barbara A Gilchrest
Jul 10, 2002·Experimental Dermatology·Robert P DellavalleLela A Lee
Oct 13, 2010·Annual Review of Pathology·Dong-Joo Cheon, Sandra Orsulic
Dec 29, 2004·Genetica·Amander T ClarkMonica J Justice
Oct 4, 2003·BMJ : British Medical Journal·C WongJohn T Lear
Jul 4, 2013·The Journal of Investigative Dermatology·Craig A Elmets, Mohammad Athar
Oct 11, 2014·The Journal of Investigative Dermatology·Sunny Y Wong, Andrzej A Dlugosz
May 1, 2009·Expert Opinion on Drug Discovery·Paola GallinariChristian Steinkühler
Jul 29, 2010·Expert Opinion on Investigational Drugs·Po-Lin SoErvin H Epstein
Aug 13, 2015·Journal of Cutaneous Pathology·Sui Wing Winney Chu, Asok Biswas
Jul 10, 2012·Biochemical and Biophysical Research Communications·Richard NuccitelliJean Y Tang
Apr 24, 2012·Hematology/oncology Clinics of North America·Deirdre J Cohen
Oct 27, 2010·The International Journal of Biochemistry & Cell Biology·Chunping YuMichele A Grimbaldeston
Aug 11, 2010·Trends in Molecular Medicine·Monique T BarakatMatthew P Scott
Dec 22, 2009·Trends in Molecular Medicine·Liyun SangHilary A Coller
Feb 10, 2009·International Journal of Radiation Oncology, Biology, Physics·Simonetta PazzagliaAnna Saran
Sep 28, 2005·The Journal of Investigative Dermatology·Juliette Lois LeeMohammad Athar
Sep 28, 2005·The Journal of Investigative Dermatology·Rudolph D PaladiniLee L Rubin
Jun 29, 2007·The Journal of Investigative Dermatology·Ellen HeitzerPeter Wolf
Jan 10, 2009·The Journal of Investigative Dermatology·Ellen HeitzerPeter Wolf
Feb 14, 2002·The Journal of Investigative Dermatology·Sarah E Millar
Dec 12, 2012·The Journal of Investigative Dermatology·Hio Chung KangAllan Balmain
Aug 5, 2011·The Journal of Investigative Dermatology·Arnaud TeichertDaniel D Bikle
Jun 4, 2004·The Journal of Investigative Dermatology·Mohammed S IkramMike Philpott
Jan 19, 2005·The Journal of Investigative Dermatology·Annika VogtErvin H Epstein
Jan 29, 2005·The Journal of Investigative Dermatology·Rebecca L H BigelowTimothy J McDonnell
Feb 18, 2006·The Journal of Investigative Dermatology·Hadi DanaeeHeather H Nelson
Aug 22, 2000·The Journal of Investigative Dermatology·X Q WangJ A Rothnagel
Sep 13, 2008·The Journal of Investigative Dermatology·Daniel D Bikle
Dec 11, 2007·Journal of Dermatological Science·Masaru HonmaHajime Iizuka
Jun 29, 2007·Human Pathology·Christian HafnerThomas Vogt
Nov 28, 2006·Dermatologic Clinics·R Bissonnette
Jun 14, 2005·The British Journal of Dermatology·C M L J TilliF C S Ramaekers
Dec 16, 2004·Annals of Human Genetics·Richard C StrangePaul R Hoban
May 13, 2005·The British Journal of Dermatology·Anna AsplundF Pontén
Jul 20, 2005·Experimental Dermatology·Anna AsplundF Pontén
Feb 5, 2005·Clinical Genetics·E Nieuwenhuis, C-c Hui
Mar 19, 2003·Journal of Cutaneous Pathology·Noriyuki MisagoYutaka Narisawa
Mar 21, 2009·The British Journal of Dermatology·P KanellouD A Spandidos
Jun 26, 2003·Experimental Dermatology·Vijaya ChaturvediBrian J Nickoloff
May 20, 2003·The British Journal of Dermatology·Z SaridakiD A Spandidos
Sep 25, 2009·The British Journal of Dermatology·P M RodustJ Eberle
May 31, 2007·The Australasian Journal of Dermatology·Cetin BoranHayri Erkol
Oct 17, 2008·International Journal of Cancer. Journal International Du Cancer·Joon Won YoonDavid Walterhouse
May 31, 2008·The British Journal of Dermatology·F BrellierThierry Magnaldo
Feb 12, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·S van der GeerG A M Krekels
Aug 3, 2006·Experimental Dermatology·Walter H C Burgdorf
Mar 13, 2008·Journal of Cutaneous Pathology·Valérie P I VidalAndreas Schedl
Sep 11, 2012·The British Journal of Dermatology·I YehP E LeBoit
Sep 2, 2011·Molecular Carcinogenesis·Karin Heby-HenricsonStephan Teglund
Feb 23, 2012·Arthritis and Rheumatism·Angelika HornJörg H W Distler
Aug 14, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yasuyuki ShimadaKen Omura
Dec 18, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·V LichteM Moehrle
Jun 16, 2010·The Australasian Journal of Dermatology·Sally E de Zwaan, Nikolas K Haass
Feb 5, 2005·Journal of the American Academy of Dermatology·Armand B CognettaMarcelo G Horenstein
Jun 28, 2005·Cancer Letters·Leela Daya-Grosjean, Sophie Couvé-Privat
Mar 2, 2016·Radiation Research·Changzhao Li, Mohammad Athar
Nov 26, 2002·The Journal of Investigative Dermatology·Michele A GrimbaldestonPrue H Hart
Apr 5, 2001·The Journal of Investigative Dermatology·X L PingH C Tsou
May 12, 2001·The Journal of Investigative Dermatology·J M BonifasErvin H Epstein
Jan 13, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Maria KasperFritz Aberger
Oct 2, 2012·Journal of Skin Cancer·Frauke NitzkiHeidi Hahn
Sep 12, 2015·International Journal of Dermatology·Livia Cristina de Melo PinoOmar Lupi
Jun 9, 2015·Molecular Carcinogenesis·Cynthia TilleyRajesh Agarwal
Oct 13, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Daniel D BikleArnaud Teichert
Mar 17, 2010·The American Journal of Pathology·Blanche Ka Ki LoKevin John McElwee
Dec 20, 2007·Radiation Research·Anna SaranC Marino
Jan 7, 2015·Canadian Journal of Physiology and Pharmacology·Daniel D Bikle
Jun 13, 2013·International Journal of Radiation Oncology, Biology, Physics·Mariateresa MancusoAnna Saran
Jan 11, 2011·Cancer Cell·Grace Y WangErvin H Epstein
Aug 29, 2014·Oral and Maxillofacial Surgery·Maria Nikolaou LazaridouIoannis Dimitrakopoulos
Jan 7, 2015·Archives of Toxicology·Yanfei JiaJingwu Xie
Feb 19, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yingying HongTiejun Li
Jul 28, 2016·Frontiers in Physiology·Daniel D BikleChia-Ling Tu
Aug 6, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ivan BergsteinRonald Crystal
Feb 11, 2015·Expert Reviews in Molecular Medicine·Silvia Pandolfi, Barbara Stecca
Jan 6, 2018·Biomedicines·Dario DidonaCarmen Cantisani
Jun 17, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yan Hua XuanSeok-Hyung Kim
Jun 5, 2002·Nature Reviews. Cancer·Ariel Ruiz i AltabaNadia Dahmane
May 8, 2001·Medical and Pediatric Oncology·Ervin H Epstein
Jul 8, 2003·The Journal of Pathology·Roland KapplerHeidi Hahn
Jul 17, 2007·Nature Medicine·Christine DierksMarkus Warmuth
Oct 4, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·B FazaaM R Kamoun
Jul 26, 2005·Journal of Neurobiology·Barbara Stecca, Ariel Ruiz i Altaba
Sep 26, 2017·Nature Genetics·Phillips Y HuangAllan Balmain
May 11, 2004·Endocrinology·Lian FanWade Bushman
Dec 12, 2012·International Journal of Oncology·Elizabeth Rose HellerAnimesh A Sinha
Dec 6, 2014·The EMBO Journal·Paola InfanteLucia Di Marcotullio
Jun 20, 2002·The Journal of Biological Chemistry·Evans C BaileyRonald L Johnson
Oct 14, 2003·The Journal of Biological Chemistry·Rebecca L H BigelowTimothy J McDonnell
Oct 6, 2004·Médecine sciences : M/S·Nicole Basset-Seguin, Nadem Soufir
Sep 29, 2015·Oncotarget·Sandeep C ChaudharyMohammad Athar
Apr 15, 2015·Oncotarget·Donna M Brennan-CrispiMỹ G Mahoney
Jun 6, 2018·Cellular Oncology (Dordrecht)·Veronique L VeenstraMaarten F Bijlsma
Mar 11, 2016·Molecular Cancer Therapeutics·Gessica FilocamoSimonetta Pazzaglia
Feb 21, 2006·Cancer Research·Christelle AdolpheBrandon Wainwright
Aug 31, 2014·Cancer Research·Mohammad AtharDavid Bickers
Mar 18, 2004·Cancer Research·Sahar HamedYves Fradet
Feb 3, 2021·Dermatologic Therapy·Lupu MihaiVlad Mihai Voiculescu
Dec 1, 2004·International Journal of Dermatology·Zuzana HolíkováJana Hercogová

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