Ultraviolet irradiation blocks cellular responses to transforming growth factor-beta by down-regulating its type-II receptor and inducing Smad7

The Journal of Biological Chemistry
Taihao QuanGary J Fisher

Abstract

Transforming growth factor-beta (TGF-beta) is a multi-functional cytokine that regulates cell growth and differentiation. Cellular responses to TGF-beta are mediated through its cell surface receptor complex, which activates transcription factors Smad2 and Smad3. Here we report that UV irradiation of mink lung epithelial cells causes near complete inhibition of TGF-beta-induced Smad2/3-mediated gene expression. UV irradiation inhibited TGF-beta-induced phosphorylation of Smad2 and subsequent nuclear translocation and DNA binding of Smad2/3. Specific cell surface binding of TGF-beta was substantially reduced after UV irradiation. This loss of TGF-beta binding resulted from UV-induced down-regulation of TGF-beta type II receptor (T beta RII) mRNA and protein. UV irradiation significantly inhibited T beta RII promoter reporter constructs, indicating that UV reduction of T beta RII expression involved transcriptional repression. In contrast to its effects on T beta RII, UV irradiation rapidly induced Smad7 mRNA and protein. Smad7 is known to antagonize activation of Smad2/3 and thereby block TGF-beta-dependent gene expression. UV irradiation stimulated Smad7 promoter reporter constructs, indicating that increased Smad7 expression r...Continue Reading

References

May 1, 1991·Molecular and Cellular Biology·Y DevaryM Karin
Jul 1, 1989·The Journal of Investigative Dermatology·E SchwartzR Fleischmajer
Feb 1, 1989·Molecular Endocrinology·P R SegariniS M Seyedin
Aug 1, 1987·The Journal of Cell Biology·L M WakefieldM B Sporn
Sep 1, 1982·Molecular and Cellular Biology·C M GormanB H Howard
Sep 23, 1994·Cell·C SachsenmaierH J Rahmsdorf
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·M E KadinD George
Aug 4, 1994·Nature·J L WranaJ Massagué
Jul 2, 1993·Cell·F López-CasillasJ Massagué
Nov 1, 1995·The Journal of Dermatology·S Kondo, D N Sauder
Aug 5, 1996·Biochemical and Biophysical Research Communications·Y S YuS Sugano
Jan 1, 1997·Journal of Photochemistry and Photobiology. B, Biology·K BenderH J Rahmsdorf
Apr 25, 1997·The Journal of Biological Chemistry·R G WellsH F Lodish
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·J N TopperD Falb
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·D TobinR Toftgård
Oct 6, 1998·Annual Review of Biochemistry·J Massagué
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·D KulmsT Schwarz
Sep 25, 1999·The Journal of Biological Chemistry·T Quan, G J Fisher
Nov 24, 1999·The Journal of Biological Chemistry·R P NagarajanY Chen
Mar 10, 2000·Cytokine & Growth Factor Reviews·J L Wrana, L Attisano

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Citations

Mar 29, 2002·Journal of Cellular Physiology·Peter Ten DijkeSusumu Itoh
Sep 30, 2006·Archives of Dermatological Research·Alexander KreuterThilo Gambichler
Mar 17, 2004·Toxicology and Applied Pharmacology·Diane E HeckJeffrey D Laskin
Sep 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Zahid N RabbaniZeljko Vujaskovic
Jan 16, 2002·Current Opinion in Genetics & Development·Lalage M Wakefield, Anita B Roberts
Sep 5, 2002·Ageing Research Reviews·Laure Rittié, Gary J Fisher
Dec 8, 2004·The Journal of Biological Chemistry·Taihao QuanGary J Fisher
Nov 17, 2005·Development, Growth & Differentiation·Koki KitamuraKenji Okazaki
Mar 13, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Young Bok LeeHyun Jeong Park
Feb 8, 2014·Japanese Journal of Ophthalmology·Ying Liu, Ding Lin
Oct 29, 2013·In Vitro Cellular & Developmental Biology. Animal·Phuc Van PhamNgoc Kim Phan
Sep 18, 2014·Journal of Natural Medicines·Zheng-Wang SunTae Hoo Yi
Mar 14, 2002·Current Rheumatology Reports·Yasuji MoriJohn Varga
Jan 14, 2004·The Journal of Cell Biology·Weibin ShiXu Cao
Aug 14, 2009·The Journal of Investigative Dermatology. Symposium Proceedings·Taihao QuanGary J Fisher
Mar 20, 2004·Photodermatology, Photoimmunology & Photomedicine·M El-MoftyA Abouzeid
Feb 6, 2004·Experimental Dermatology·Lei YinTakuo Tsuji
Aug 23, 2007·The British Journal of Dermatology·M Yaar, B A Gilchrest
Aug 23, 2002·The Journal of Investigative Dermatology·TaiHao QuanGary J Fisher
Mar 5, 2002·The Journal of Investigative Dermatology·Taihao QuanGary J Fisher
Feb 18, 2005·Journal of Biochemistry and Molecular Biology·Seok Hee Park
Jan 29, 2011·The Biochemical Journal·Xiaohua Yan, Ye-Guang Chen
Dec 3, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Bin SunBertha Chen
Mar 13, 2016·The Journal of Investigative Dermatology·Masaki KobayashiShingo Sakai
May 26, 2007·The American Journal of Pathology·Laure RittiéJames T Elder
Sep 24, 2005·Clinics in Dermatology·Uwe-Frithjof Haustein
Mar 15, 2018·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·H YoshidaY Takahashi
Feb 9, 2018·Photochemistry and Photobiology·Wongnapa NakyaiCéline Viennet

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