Ultraviolet irradiation of the eye and Fos-positive neurons induced in trigeminal brainstem after intravitreal or ocular surface transient receptor potential vanilloid 1 activation.

Neuroscience
Zheng ChangD A Bereiter

Abstract

The interior structures of the eye are well supplied by the trigeminal nerve; however, the function of these afferent fibers is not well defined. The aim of this study was to use c-fos like immunohistochemistry (Fos-LI) to map the trigeminal brainstem complex after intravitreal microinjection or ocular surface application of capsaicin, a selective transient receptor potential vanilloid 1 (TRPV1) agonist in male rats under barbiturate anesthesia. The effect of ocular inflammation on Fos-LI was tested 2 or 7 days after UV irradiation of the eye. In non-inflamed controls, intravitreal capsaicin produced peaks of Fos-LI at the trigeminal subnucleus interpolaris/caudalis (Vi/Vcvl) transition and in superficial laminae at the caudalis/upper cervical cord (Vc/C1) junction regions. At the Vc/C1 junction intravitreal capsaicin induced Fos-LI in a dose-dependent manner, while at the Vi/Vcvl transition responses were similar after vehicle or capsaicin injections. Two days, but not 7 days, after UV irradiation intravitreal and ocular surface capsaicin-evoked Fos-LI at the Vc/C1 junction and nucleus tractus solitarius (NTS) were markedly enhanced, whereas the responses at the Vi/Vcvl transition were not different from non-inflamed controls....Continue Reading

References

May 22, 1991·The Journal of Comparative Neurology·A YoshidaC Y Chiang
Nov 15, 1989·The Journal of Comparative Neurology·C MolanderG Grant
Jul 15, 1987·The Journal of Comparative Neurology·C F Marfurt, D R Del Toro
Jul 15, 1987·Experientia·R A StoneA M Laties
Nov 1, 1986·Experimental Eye Research·A ZuazoC Belmonte
Mar 15, 1985·The Journal of Comparative Neurology·M Kalia, K Fuxe
Nov 1, 1971·Experimental Eye Research·C BelmonteA Gallego
Apr 6, 1999·Pharmacology & Therapeutics·H Izumi
Feb 13, 2001·Brain Research·H Ichikawa, T Sugimoto
Oct 11, 2003·Anatomy and Embryology·Suzhen GongMark S LeDoux
Apr 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Harumitsu HirataDavid A Bereiter
Dec 30, 2004·Investigative Ophthalmology & Visual Science·Eduard SchmidJosef Troger
Jan 27, 2005·Investigative Ophthalmology & Visual Science·Josef TrogerReiner Fischer-Colbrie
Jul 29, 2005·Journal of Neurophysiology·David A BereiterHarumitsu Hirata
Jul 29, 2006·Brain Research Reviews·Josef TrogerEduard Schmid
Mar 14, 2007·Journal of Neurophysiology·Lieju LiuS A Simon
Feb 6, 2008·Emergency Medicine Clinics of North America·James M Dargin, Robert A Lowenstein
Feb 26, 2008·Journal of Dental Research·A M PatwardhanK M Hargreaves
Jan 24, 2009·Experimental Dermatology·Young Mee LeeJin Ho Chung
Mar 17, 2009·Neuroscience·K OkamotoD A Bereiter
Jul 22, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mauro LeonelliLuiz R G Britto
Nov 10, 2009·Pharmacology & Therapeutics·Khadija Alawi, Julie Keeble
Mar 9, 2010·Pain·Keiichiro OkamotoDavid A Bereiter

❮ Previous
Next ❯

Citations

Jan 10, 2016·Neurobiology of Disease·Pierre-Serge LaunayAnnabelle Reaux Le Goazigo
Sep 4, 2012·The European Journal of Neuroscience·Keiichiro OkamotoDavid A Bereiter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.