PMID: 2106461Mar 1, 1990Paper

Ultraviolet light immunomodulation of canine islets for prolongation of allograft survival

Diabetes
N S KenyonR Alejandro

Abstract

Ultraviolet (UV) light treatment of donor islets has been shown to be effective for the prolongation of islet allograft survival in rodent models. This study evaluated UV as an immunomodulator of canine islets. The effects of UV irradiation on islet secretory function in vitro revealed a trend of increasing basal insulin release with increasing doses of UV and a corresponding significant decrease in glucose-mediated insulin release (expressed as percentage of basal fractional insulin release) beginning at UV light exposures of 200-300 J/m2 (n = 3, P less than 0.05). Proliferative responses to UV-irradiated allogeneic peripheral blood leukocytes and islets were significantly decreased by 53-112% (P less than 0.05) in 27 of 29 mixed-lymphocyte cultures and by 35-74% (P less than 0.05) in 4 of 5 mixed-lymphocyte islet culture experiments, respectively, beginning at 200-600 J/m2. Autotransplantation of nonirradiated (n = 8) and irradiated islets (600 J/m2, n = 6) resulted in a 1-mo graft survival rate of 75% for the control group and 50% for the irradiated group. Allotransplantation of irradiated islets (600 J/m2) into either nonimmunosuppressed recipients (1 donor to 1 recipient, n = 8) or recipients of subimmunosuppressive doses ...Continue Reading

Citations

Jan 1, 1992·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S J Sullivan
Jan 1, 1998·Cytotechnology·N S Kenyon, C Ricordi
May 18, 1999·Xenotransplantation·H S Deol, B E Tuch
Jan 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·K FederlinB J Hering
Jun 10, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N M Luan, H Iwata
Jan 1, 1994·Cell Transplantation·M P van der BurgH G Gooszen
Oct 4, 2018·Tissue Engineering. Part a·Rei KuwabaraHiroo Iwata
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·R Alejandro
Aug 5, 2009·Cell Transplantation·Lane C K CoffeyNorma S Kenyon

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