Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling

International Journal of Molecular Medicine
Novi KusumaningrumJin Ho Chung

Abstract

Gasdermin (GSDM)‑C is a member of the GSDM gene family and is expressed in the epithelial cells of various tissue types, including skin. GSDMC expression is induced by ultraviolet (UV) irradiation and contributes to UV‑induced matrix metalloproteinase 1 expression in human skin keratinocytes. However, how UV irradiation induces GSDMC expression remains unclear. The present study aimed to investigate the role of transient receptor potential cation channel subfamily V member 1 (TRPV1) and a calcium/calcineurin‑signaling pathway in UV‑induced GSDMC expression in human skin keratinocytes. Suppression of TRPV1 activity by treatment with the TRPV1 antagonists capsazepine and ruthenium red significantly reduced UV‑induced GSDMC expression, whereas direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased GSDMC expression. The results demonstrated that extracellular calcium and calcineurin activity may be necessary for UV‑induced GSDMC expression in HaCaT cells. In addition, UV‑induced GSDMC expression was either decreased or increased following knockdown or overexpression of nuclear factor of activated T‑cells, cytoplasmic 1 (NFATc1), respectively. These data suggested that TRPV1 may serve an important role in the induction ...Continue Reading

References

Nov 14, 1997·The New England Journal of Medicine·G J FisherJ J Voorhees
Feb 5, 1998·Experimental Dermatology·V M Kähäri, U Saarialho-Kere
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A R NelsonL M Matrisian
Sep 1, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·N SaekiT Shiroishi
Nov 30, 2000·The Journal of Biological Chemistry·G R Crabtree
Feb 13, 2001·Seminars in Cell & Developmental Biology·M D BootmanP Lipp
Nov 1, 2001·Annual Review of Cell and Developmental Biology·M D Sternlicht, Z Werb
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Sep 5, 2002·Ageing Research Reviews·Laure Rittié, Gary J Fisher
Dec 18, 2002·Annals of the New York Academy of Sciences·Peter BrenneisenKarin Scharffetter-Kochanek
Jan 20, 2004·Developmental Biology·Robert A Schulz, Katherine E Yutzey
Sep 1, 2004·Biochemical and Biophysical Research Communications·Benjamin J Wilkins, Jeffery D Molkentin
May 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gerard P AhernXiang-bin Wang
Nov 22, 2005·Free Radical Biology & Medicine·Cécile MazièreJean-Claude Mazière
Apr 4, 2006·Bioorganic & Medicinal Chemistry Letters·Harshad K RamiJohn B Davis
Jan 18, 2008·The Journal of Investigative Dermatology·N P M SmitJ Van Pelt
Jan 23, 2008·The Clinical Journal of Pain·Helena KnotkovaArpad Szallasi
Aug 19, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R J FlockhartN J Reynolds
May 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Hui LiHuai-Hu Chuang
Jul 4, 2012·Cold Spring Harbor Perspectives in Biology·Martin D Bootman
Oct 29, 2017·Photodermatology, Photoimmunology & Photomedicine·Sangbum HanJin Ho Chung
Feb 13, 2018·Journal of Dermatological Science·Novi KusumaningrumJin Ho Chung

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Citations

Apr 26, 2020·International Journal of Immunogenetics·Jiamin WuTianbo Jin
Dec 29, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Joo Han WooJoo Hyun Nam
Jul 3, 2021·International Journal of Molecular Sciences·Michelle D Bagood, R Rivkah Isseroff

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