Ultraviolet light induced injury: immunological and inflammatory effects

Immunology and Cell Biology
G J ClydesdaleH K Muller

Abstract

This article reviews many of the complex events that occur after cutaneous ultraviolet (UV) exposure. The inflammatory changes of acute exposure of the skin include erythema (sunburn), the production of inflammatory mediators, alteration of vascular responses and an inflammatory cell infiltrate. Damage to proteins and DNA accumulates within skin cells and characteristic morphological changes occur in keratinocytes and other skin cells. When a cell becomes damaged irreparably by UV exposure, cell death follows via apoptotic mechanisms. Alterations in cutaneous and systemic immunity occur as a result of the UV-induced inflammation and damage, including changes in the production of cytokines by keratinocytes and other skin-associated cells, alteration of adhesion molecule expression and the loss of APC function within the skin. These changes lead to the generation of suppressor T cells, the induction of antigen-specific immunosuppression and a lowering of cell-mediated immunity. These events impair the immune system's capacity to reject highly antigenic skin cancers. This review gives an overview of the acute inflammatory and immunological events associated with cutaneous UV exposure, which are important to consider before dealing...Continue Reading

References

Oct 1, 1977·Journal of the National Cancer Institute·M L KripkeM S Fisher
Nov 1, 1976·The British Journal of Dermatology·A Woodcock, I A Magnus
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M I GreeneB Benacerraf
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R W HartA D Woodhead
Apr 1, 1978·The British Journal of Dermatology·A P Warin
Feb 1, 1979·The Journal of Investigative Dermatology·W H EaglsteinN Mizuno
Nov 1, 1979·The British Journal of Dermatology·W L MorisonJ I Krugler
Sep 28, 1978·Archives of Dermatological Research·H C Wulf
Mar 1, 1977·The Journal of Investigative Dermatology·I Willis, L Cylus
Mar 1, 1977·The Journal of Investigative Dermatology·W L MorisonJ A Parrish
Oct 1, 1977·The Journal of Investigative Dermatology·M KumakiriI Willis
Apr 1, 1975·The Journal of Investigative Dermatology·D W OwensD Troll
Jan 1, 1975·Journal of Cutaneous Pathology·R L Olson, M A Everett
Mar 1, 1976·The Journal of Investigative Dermatology·K H Kaidbey, A K Kurban
May 1, 1976·The British Journal of Dermatology·C A Ramsay, A V Challoner
Nov 1, 1992·The Journal of Investigative Dermatology·A H Enk, S I Katz
Jul 1, 1992·Immunology Today·F P Noonan, E C De Fabo
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M L KripkeD B Yarosh
Mar 1, 1990·The Journal of Investigative Dermatology·M J GlassJ W Streilein
Oct 1, 1991·The Journal of Investigative Dermatology·M VermeerJ W Streilein
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D E BrashJ Pontén
May 1, 1990·The Journal of Clinical Investigation·J KrutmannC A Elmets
Apr 1, 1991·The Journal of Investigative Dermatology·R KirnbauerT A Luger
Oct 1, 1990·Photochemistry and Photobiology·F P Noonan, E C De Fabo
Jul 1, 1990·The Journal of Investigative Dermatology·K Weber-Matthiesen, W Sterry
Nov 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·D B Yarosh, V Yee
Jun 1, 1990·The Journal of Investigative Dermatology·J AnselS Hefeneider
Dec 1, 1990·The Journal of Investigative Dermatology·T A Luger, T Schwarz
Apr 1, 1990·The Journal of Clinical Investigation·V A TronD N Sauder
Jun 1, 1990·The Journal of Investigative Dermatology·A UrbanskiT A Luger

❮ Previous
Next ❯

Citations

Nov 11, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H Ott, J M Baron
Feb 24, 2006·Archives of Dermatological Research·Michaela KuhnHelmut Sies
Sep 17, 2009·Archives of Dermatological Research·Visalini Muthusamy, Terrence J Piva
Sep 28, 2013·Archives of Dermatological Research·Visalini Muthusamy, Terrence J Piva
Jun 21, 2006·Medical Microbiology and Immunology·Uwe Ritter, Anke Osterloh
Jul 27, 2007·Cancer Causes & Control : CCC·Mark P PurdueSophia S Wang
Sep 15, 2012·Current Diabetes Reports·Klaus BadenhoopMarissa Penna-Martinez
Jun 1, 2005·Biochimica Et Biophysica Acta·Leena Latonen, Marikki Laiho
Jul 10, 2012·Nature Medicine·Jamie J BernardRichard L Gallo
Sep 18, 2012·Carcinogenesis·Andrea L BenedictAlbena T Dinkova-Kostova
Jan 5, 2008·Photochemistry and Photobiology·Mary NorvalJoanna Narbutt
Jan 5, 2008·Photochemistry and Photobiology·H Konrad MullerGregory M Woods
Sep 1, 2012·Photochemistry and Photobiology·Daniel WrightGianfranco Liguri
Jun 11, 2004·Annual Review of Nutrition·Helmut Sies, Wilhelm Stahl
Jul 5, 2012·PloS One·Benjamin WeinkaufMartin Schmelz
May 31, 2006·Annales de dermatologie et de vénéréologie·L Meunier
Aug 24, 2013·International Journal of Molecular Sciences·Visalini Muthusamy, Terrence J Piva
Mar 24, 2004·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Alena SvobodováDaniela Walterová
Aug 29, 2006·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Alena SvobodovaJitka Vostalova
Jun 5, 2013·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jitka VostalovaJitka Ulrichova
Dec 24, 2013·Colloids and Surfaces. B, Biointerfaces·C C LiY W Chen-Yang
Oct 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Paul TalalayAlbena T Dinkova-Kostova
Jan 24, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Thomas SychaEduard Auff
Oct 16, 2013·Antioxidants & Redox Signaling·Rachel E B WatsonMichael J Sherratt
Oct 5, 2010·Journal of Molecular Histology·Caliandra Pinto AraújoJean Nunes dos Santos
Aug 26, 2014·Cancer Causes & Control : CCC·Demin LuJie Jin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.