Ultraviolet radiation transmittance of the mouse eye and its individual media components

Experimental Eye Research
Johanna Tukler HenrikssonJames E Walsh

Abstract

Recently, the mouse has become the preferred animal model in ophthalmic research. Therefore, there is a need for enhanced understanding of the mouse eye to validate its use in different experimental setting. The purpose of this study was to determine the ocular transmittance of the whole mouse eye, the cornea and the crystalline lens, particularly in the ultraviolet radiation (UVR) wavebands. This was carried out using a non-cuvette based fiber optic spectrometer system and the resulting transmittance curves were compared with published cone spectral response curves and mouse ocular transmittance data. First, transmittance curves of the whole mouse eye were measured by removing a small disc of sclera from the posterior pole to provide an anterior to posterior optical path. No statistical difference was found between left and right eye in each of the four mice sampled, therefore, all eight eyes were included in the final statistical analysis. The average of five test measurements from each left and right eye for the four test mice showed a transmittance cut off at approximately 310 nm. Secondly, the cornea with a scleral rim was excised and transmittance curves obtained for all eight eyes. This data showed an average transmittan...Continue Reading

References

Aug 1, 1992·Vision Research·T G Gorgels, D van Norren
Nov 1, 1974·Vision Research·D V Norren, J J Vos
Aug 1, 1969·The Journal of Physiology·G F Cooper, J G Robson
Aug 1, 1969·The Journal of Physiology·G F Cooper, J G Robson
Jul 1, 1984·American Journal of Optometry and Physiological Optics·A P CullenS E Jany
Jan 1, 1994·Documenta Ophthalmologica. Advances in Ophthalmology·W AmbachA Daxer
Nov 1, 1993·The British Journal of Ophthalmology·M T Coroneo
Nov 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E P ZhangF Hoffmann
Feb 24, 2000·The British Journal of Ophthalmology·C A McCartyH R Taylor
Nov 18, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·U E Siebeck, N J Marshall
Jan 12, 2005·Experimental Eye Research·Peter Gouras, Bjorn Ekesten
Mar 7, 2006·Vision Research·Elena García de la CeraSusana Marcos
May 19, 2007·Vision Research·Gary A Williams, Gerald H Jacobs
Aug 31, 2007·Nature Genetics·Richard Mott

❮ Previous
Next ❯

Citations

Feb 21, 2014·Proceedings. Biological Sciences·R H Douglas, G Jeffery
Feb 15, 2013·Journal of Neurophysiology·Lu YinWilliam H Merigan
Sep 24, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ethan D BuhrRussell N Van Gelder
Jun 21, 2017·Neuroscience·Motoharu TakaoTakeshi Morita
Feb 28, 2018·Learning & Behavior·David J Pritchard, Susan D Healy
Mar 8, 2018·Nature Communications·Jing TangGengfeng Zheng
Apr 7, 2016·Nature·Maximilian Joesch, Markus Meister
Aug 31, 2019·Biomedical Optics Express·Gopal Swamy JayabalanJoseph T Fan
Oct 23, 2018·Investigative Ophthalmology & Visual Science·Marie-Paule Felder-SchmittbuhlGianluca Tosini
May 27, 2011·The Journal of Experimental Biology·Christopher HoggGlen Jeffery
Oct 17, 2021·Journal of Neuroinflammation·Eric B MillerMarie E Burns
Dec 1, 2021·The Journal of Clinical Investigation·Jakub BoguslawskiMaciej Wojtkowski
Jan 21, 2022·PloS One·Luca Abballe, Hiroki Asari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.