Ulva conglobata, a marine algae, has neuroprotective and anti-inflammatory effects in murine hippocampal and microglial cells

Neuroscience Letters
Da-Qing JinJung-Soo Han

Abstract

It has been reported that inflammatory processes are associated with the pathophysiology of Alzheimer's disease (AD), and the treatment of AD using anti-inflammatory agents slows the progress of AD. Marine algae have been utilized in food products as well as in medicine products for a variety of purposes. In this study, we investigated the neuroprotective effects of methanol extracts of Ulva conglobata (U. conglobata), a marine algae, on glutamate-induced neurotoxicity in the murine hippocampal HT22 cell line and the anti-inflammatory effects on interferon gamma (IFN-gamma)-induced microglial activation in BV2 cells. U. conglobata methanol extracts significantly attenuated the neurotoxicity induced by glutamate in HT22 cells and inhibited nitric oxide production induced by IFN-gamma in BV2 cells. U. conglobata methanol extract treatments were also examined and it was found that they almost completely suppressed the expression of the proinflammatory enzyme cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS). These results suggest that U. conglobata possesses therapeutic potential for combating neurodegenerative diseases associated with neuroinflammation.

References

Oct 1, 1989·Journal of Neuroimmunology·S ItagakiD Selkoe
May 1, 1995·The Journal of Comparative Neurology·C D BrederR P Kraig
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·W E KaufmannP Isakson
Mar 1, 1997·Neurology·W F StewartE J Metter
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·T D WarnerJ R Vane
Aug 29, 2000·Neuroscience Letters·D CasperP Werner
Dec 5, 2000·Current Pharmaceutical Design·D O Stichtenoth, J C Frölich
Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mariona GrauperaJuan Rodés
Aug 19, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Edith G McGeer, Patrick L McGeer
May 11, 2005·Biochemical and Biophysical Research Communications·Da-Qing JinJung-Soo Han
Jan 13, 2006·Ecotoxicology and Environmental Safety·Melek Türker Saçan, Işil Akmehmet Balcioğlu

❮ Previous
Next ❯

Citations

Jun 4, 2013·Cancer Cell International·Jin-Ching LeeHsueh-Wei Chang
Jun 16, 2011·Marine Drugs·Ratih Pangestuti, Se-Kwon Kim
Dec 24, 2013·Journal of Animal Science and Biotechnology·Krystal K LumXin Gen Lei
Feb 24, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hyo Won JungYong-Ki Park
Apr 25, 2018·Biomedical Engineering Online·Chong NingShi-Ying Huang
Oct 28, 2019·Current Alzheimer Research·Anuruddhika Udayangani RathnayakeHee-Guk Byun
Jul 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rexie P MagdugoNathalie Bourgougnon
Aug 30, 2017·Journal of Toxicology and Environmental Health. Part a·Eduarda Lopes-CostaAlice A Ramos
Oct 27, 2018·Marine Drugs·Ana R CircuncisãoArtur M S Silva
Jun 27, 2019·International Journal of Molecular Sciences·Maria Cristina BarbalaceCristina Angeloni
Dec 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Biswajita PradhanMrutyunjay Jena

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.