Umbilical Arterial Blood Sampling Alters Cerebral Tissue Oxygenation in Very Low Birth Weight Neonates

The Journal of Pediatrics
Jonathan P MintzerEdmund F La Gamma

Abstract

To evaluate the magnitude, consistency, and natural history of reductions in cerebral regional tissue oxygenation (CrSO2) during umbilical arterial (UA) blood sampling in very low birth weight neonates. Data were collected during a prospective observational near-infrared spectroscopy survey conducted on a convenience sample of 500-1250 g neonates during the first 10 postnatal days. A before-after analysis of UA blood sampling effects on CrSO2 absolute values and variability was performed. The present analysis was not designed a priori and was conducted following the bedside observation of CrSO2 decrements contiguous with UA blood draws. Fifteen very low birth weight neonates had 201 UA blood draws. Baseline CrSO2 (mean ± SEM) decreased following UA blood sampling, from 70 ± 1% to a nadir of 63 ± 1% (P < .001) occurring 4 ± 3 (range 2-24) minutes following blood draws. CrSO2 subsequently increased to 70 ± 1% (P < .001 compared with nadir) at 10 ± 4 (range 4-28) minutes following UA blood sampling. Coefficients of variation (mean ± SEM) increased from 0.02 ± 0.001 at baseline to 0.05 ± 0.004 (P < .001), followed by a decrease to 0.03 ± 0.003 (P < .001 for all comparisons), thus denoting increased CrSO2 variability following UA bl...Continue Reading

References

Oct 4, 2006·Pediatrics·Seetha ShankaranUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
May 15, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jon KaufmanRobert H Friesen
Aug 12, 2008·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Myrna GordonJohn A Widness
Jun 12, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·S McNeillB Engelhardt
Aug 25, 2010·Pediatrics·Barbara J StollUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Dec 1, 2010·American Journal of Perinatology·Abdul HaleemEdmund F La Gamma
Jan 22, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·A PetrovaR Mehta
Apr 1, 2011·The Journal of Thoracic and Cardiovascular Surgery·Anselm UebingHans-Heiner Kramer
Apr 21, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·Z ErgazB Bar-Oz
Nov 7, 2013·Pediatric Research·Laura R MentUNKNOWN Gene Targets for IVH Study Group
May 21, 2014·Pediatrics·Shaneela ShahidSandesh Shivananda
Jan 9, 2015·BMJ : British Medical Journal·Simon Hyttel-SorensenGorm Greisen
Jan 23, 2015·Journal of Perinatology : Official Journal of the California Perinatal Association·A O GuptaJ Ramasethu
May 1, 2015·Journal of Perinatology : Official Journal of the California Perinatal Association·J P MintzerE F LaGamma
May 3, 2015·Journal of Pediatric Surgery·Paolo MontaldoPaolo Giliberti

❮ Previous
Next ❯

Citations

May 5, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·P KorčekG Naulaers
Jan 11, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Jonathan P Mintzer, Catherine Messina
Aug 28, 2021·American Journal of Perinatology·Santina A ZanelliZachary A Vesoulis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.