Umbilical artery blood gas parameters in neonates with early onset seizures who die

BJOG : an International Journal of Obstetrics and Gynaecology
Keith P Williams, Avash Singh

Abstract

To relate umbilical artery blood gas parameters to mortality among neonates with hypoxic-ischaemic encephalopathy related to early onset seizures. Population cohort study. British Columbia Women's Hospital. Forty-seven infants at >or=32 weeks of gestation admitted to NICU with early onset seizures secondary to hypoxic-ischaemic encephalopathy with umbilical artery blood gases done at delivery. Patients were divided into two groups: (1) Infants with neonatal seizures who survived, and (2) infants with neonatal seizures who died related to hypoxic-ischaemic encephalopathy complications. Comparison of umbilical artery pH, PO(2), PCO(2), base deficit was done between the two groups with Student's t tests. Umbilical artery pH, PO(2), PCO(2) and base deficit. The PO(2) was significantly higher in the group that expired (18.36 +/- 9.15 vs 12.33 +/- 7.51). There were no significant differences in any other blood gas parameters between the groups. Neither the umbilical artery pH nor base deficit is predictive of neonatal death in infants with hypoxic-ischaemic encephalopathy with seizures. The finding of a high PO(2) in neonates who died may indicate an inability of those infants to efficiently extract oxygen from blood.

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Citations

Jan 29, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Maria JonssonUlf Hanson
Jul 23, 2015·Iranian Journal of Pediatrics·Mousa Ahmadpour-KachoAli Bijani
Sep 4, 2020·Clinical and Experimental Pediatrics·Behnaz BasiriMohammadmahdi Sabahi

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