Umbilical cord blood and placental mercury, selenium and selenoprotein expression in relation to maternal fish consumption

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Christy L GilmanMarla J Berry

Abstract

Seafood is an important source of nutrients for fetal neurodevelopment. Most individuals are exposed to the toxic element mercury through seafood. Due to the neurotoxic effects of mercury, United States government agencies recommend no more than 340g (12oz) per week of seafood consumption during pregnancy. However, recent studies have shown that selenium, also abundant in seafood, can have protective effects against mercury toxicity. In this study, we analyzed mercury and selenium levels and selenoprotein mRNA, protein, and activity in placenta of a cohort of women in Hawaii in relation to maternal seafood consumption assessed with dietary surveys. Fish consumption resulted in differences in mercury levels in placenta and cord blood. When taken as a group, those who consumed no fish exhibited the lowest mercury levels in placenta and cord blood. However, there were numerous individuals who either had higher mercury with no fish consumption or lower mercury with high fish consumption, indicating a lack of correlation. Placental expression of selenoprotein mRNAs, proteins and enzyme activity was not statistically different in any region among the different dietary groups. While the absence of seafood consumption correlates with l...Continue Reading

References

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Jan 26, 2012·Environmental Health Perspectives·Margaret R KaragasSusan Korrick

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Citations

Jan 25, 2016·The Science of the Total Environment·Mengling TangWeiping Liu
Oct 12, 2016·Nihon eiseigaku zasshi. Japanese journal of hygiene·Kanae KaritaKatsuyuki Murata
Feb 18, 2020·Reproductive Toxicology·Julia E RagerRebecca C Fry

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Methods Mentioned

BETA
PCR

Software Mentioned

Image Studio
Absolute Quantification

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