Umbilical cord blood cells for the treatment of preterm white matter injury: Potential effects and treatment options.

Journal of Neuroscience Research
Han QiuLaishuan Wang

Abstract

Preterm birth is a global public health problem. A large number of preterm infants survive with preterm white matter injury (PWMI), which leads to neurological deficits, and has multifaceted etiology, clinical course, monitoring, and outcomes. The principal upstream insults leading to PWMI initiation are hypoxia-ischemia and infection and/or inflammation and the key target cells are late oligodendrocyte precursor cells. Current PWMI treatments are mainly supportive, and thus have little effect in terms of protecting the immature brain or repairing injury to improve long-term outcomes. Umbilical cord blood (UCB) cells comprise abundant immunomodulatory and stem cells, which have the potential to reduce brain injury, mainly due to anti-inflammatory and immunomodulatory mechanisms, and also through their release of neurotrophic or growth factors to promote endogenous neurogenesis. In this review, we briefly summarize PWMI pathogenesis and pathophysiology, and the specific properties of different cell types in UCB. We further explore the potential mechanism by which UCB can be used to treat PWMI, and discuss the advantages of and potential issues related to UCB cell therapy. Finally, we suggest potential future studies of UCB cell ...Continue Reading

References

Jul 1, 1995·Annals of Neurology·M J RivkinL Villa-Komaroff
Feb 27, 2001·Bone Marrow Transplantation·N M-ReboredoR G Villaescusa
Jan 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lars M BjorklundOle Isacson
Dec 8, 2004·Best Practice & Research. Clinical Obstetrics & Gynaecology·Ian Rogers, Robert F Casper
Oct 14, 2005·The New England Journal of Medicine·Seetha ShankaranUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Oct 5, 2006·JAMA : the Journal of the American Medical Association·Martin BaxOlof Flodmark
Oct 24, 2007·Experimental Hematology·Carmella van de VenMitchell S Cairo
Jan 8, 2008·Lancet·Robert L GoldenbergRoberto Romero
May 13, 2008·Lancet·Katarina Le BlancUNKNOWN Developmental Committee of the European Group for Blood and Marrow Transplantation
Oct 17, 2008·Journal of Neuroscience Research·A A HallK R Pennypacker
Oct 3, 2009·The New England Journal of Medicine·Denis V AzzopardiUNKNOWN TOBY Study Group
Jan 13, 2010·Acta Paediatrica·F GroenendaalL S de Vries
Jun 8, 2010·Cell Transplantation·Hiroshi YagiMartin L Yarmush
Sep 10, 2011·Nature Reviews. Immunology·Katherine Y King, Margaret A Goodell
Dec 14, 2011·The Journal of Biological Chemistry·Derrick D RoweKeith R Pennypacker
Dec 14, 2011·Annals of Neurology·Luigi TitomanlioPierre Gressens
May 23, 2012·Lancet Neurology·Bobbi Fleiss, Pierre Gressens
Feb 19, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Suleimman A Al-SweedanBasil Obeidat
Apr 23, 2013·Biochemical and Biophysical Research Communications·Shuken BokuIchiro Kusumi
Aug 22, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hongqi XinMichael Chopp
Dec 24, 2013·Progress in Neurobiology·Ted Weita LaiYu Tian Wang

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