Umbilical cord blood-derived cellular products for cancer immunotherapy

Cytotherapy
Jeannette CanyNina Shah

Abstract

Although the vast majority of experience with umbilical cord blood (CB) centers on hematopoietic reconstitution, a recent surge in the knowledge of CB cell subpopulations as well as advances in ex vivo culture technology have expanded the potential of this rich resource. Because CB has the capacity to generate the entire hematopoietic system, we now have a new source for natural killer, dendritic and T cells for therapeutic use against malignancies. This Review will focus on cellular immunotherapies derived from CB. Expansion techniques, ongoing clinical trials and future directions for this new dimension of CB application are also discussed.

References

Dec 31, 2002·Blood·Sonia A PerezMichael Papamichail
Jun 13, 2003·European Journal of Haematology·Hidehisa TanakaHiroshi Hara
May 4, 2004·Nature Medicine·Carl G FigdorCornelis J M Melief
Sep 11, 2004·Clinical and Diagnostic Laboratory Immunology·Sunwoong S ChoiRobert L Roberts
Jan 18, 2005·Bone Marrow Transplantation·J R PasswegA Tichelli
Feb 3, 2005·International Journal of Cancer. Journal International Du Cancer·Andreas HombachHinrich Abken
Aug 3, 2005·The Journal of Experimental Medicine·Hiroyuki YoneyamaKouji Matsushima
Nov 15, 2007·Stem Cells and Development·I-Ting KaoShiaw-Min Hwang
Jun 5, 2008·Cancer Immunology, Immunotherapy : CII·Tanja D de GruijlRik J Scheper
May 30, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Jian Gang JinHu Chen
Jan 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey E RubnitzWing Leung
Oct 30, 2010·Immunity·Karolina PaluckaIra Mellman
Mar 23, 2012·Nature Reviews. Cancer·Karolina Palucka, Jacques Banchereau
Jan 4, 2013·PloS One·William K DeckerWilliam G Wierda
Jan 15, 2013·Frontiers in Immunology·Stephanie Krieg, Evelyn Ullrich
Jan 26, 2013·Blood·Luca Gattinoni, Nicholas P Restifo
Apr 12, 2013·Clinical and Experimental Immunology·C M U Hilkens, J D Isaacs

❮ Previous
Next ❯

Citations

Aug 25, 2015·Stem Cells International·J-F StoltzY He
Oct 9, 2016·Cytometry. Part B, Clinical Cytometry·Dara M Strauss-AlbeeCatherine A Blish
Mar 5, 2020·Cancer Immunology, Immunotherapy : CII·Raquel TarazonaRafael Solana
Sep 9, 2019·Bulletin of Experimental Biology and Medicine·Yu V Gel'mE V Abakushina
May 12, 2017·Frontiers in Immunology·Markus GranzinEvelyn Ullrich
Nov 7, 2017·Expert Opinion on Biological Therapy·Katalin Balassa, Vanderson Rocha
Apr 10, 2020·Gynecologic Oncology·Janneke S Hoogstad-van EvertHarry Dolstra
Apr 5, 2021·Acta Biomaterialia·Chandralekha ChatterjeeCornelia Lee-Thedieck

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.