PMID: 9540928Apr 16, 1998Paper

Umbilical cord plasma glutathione S-transferase alpha 1-1 levels as a marker of neonatal hepatocellular integrity

Obstetrics and Gynecology
M F KnapenE A Steegers

Abstract

To investigate possible delivery-related impaired neonatal hepatocellular integrity by assessment of arterial and venous umbilical cord plasma levels of glutathione S-transferase Alpha 1-1. Glutathione S-transferase Alpha 1-1 levels were assessed in arterial and venous umbilical cord, and maternal venous plasma samples. The influence of maternal, delivery, and neonatal characteristics on arterial umbilical cord glutathione S-transferase Alpha 1-1 levels was studied, using linear regression analysis after log-transformation. Median (range) arterial umbilical cord glutathione S-transferase Alpha 1-1 plasma levels were higher than venous umbilical cord levels (9.68 [0.64-1125] microg/L and 7.66 [0.78-987.5] microg/L, respectively, P < .005). Median (range) arterial and venous umbilical cord glutathione S-transferase Alpha 1-1 levels were higher than, and did not correlate with, maternal venous plasma levels (8.79 [1.79-183] microg/L and 6.47 [1.58-164.5] microg/L versus 1.47 [0.46-10.4] microg/L, P < .001). Neonates born vaginally demonstrated higher median (range) levels than those delivered by cesarean (13.41 [1.02-1125] microg/L and 5.73 [0.64-172.90] microg/L, respectively, P < .001). Neonates with unfavorable pH (arterial pH ...Continue Reading

References

May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M el Mouelhi, F C Kauffman
Feb 28, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·G J BeckettJ D Hayes

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Citations

Apr 17, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M F KnapenE A Steegers
Jun 28, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M F Knapen
Apr 23, 1999·Early Human Development·M F KnapenE A Steegers

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