PMID: 11904602Mar 21, 2002Paper

Umbilical cord plasma leptin is increased in preeclampsia

American Journal of Obstetrics and Gynecology
Rønnaug A OdegårdRigmor Austgulen

Abstract

The objective of this study was to compare umbilical cord plasma leptin between infants of mothers who experienced preeclampsia and infants of control subjects and to study the relation between cord plasma leptin and infant obesity, as indicated by ponderal index. On the basis of a population of approximately 13,000 deliveries, we compared cord plasma leptin from preeclamptic (n = 256 women) and control pregnancies (n = 607 women) after taking the differences in gestational age and ponderal index into account. Cord plasma leptin increased strongly with gestational age, both in the preeclampsia group and the control subjects (P <.01), but at each gestational age the preeclampsia group had higher leptin levels than control subjects (P <.01). Adjustment for the higher ponderal index among control subjects (P <.05) did not alter the difference in leptin levels between the groups. We found higher levels of umbilical cord plasma leptin in infants of mothers who had preeclampsia (compared with infants of control subjects) after adjusting for differences in gestational age, gender, and infant ponderal index.

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Citations

Nov 25, 2005·Cancer Investigation·Michele R FormanYawei Zhang
Apr 3, 2004·Acta Obstetricia Et Gynecologica Scandinavica·Arsenio SpinilloLaura Montanari
Dec 17, 2014·Reproductive Toxicology·Jeremy Michals SchrawMichele R Forman
Jun 21, 2014·American Journal of Obstetrics and Gynecology·Ingvild V AlsnesInger Økland
Jun 19, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·D JaskolkaC K Kramer
Jan 23, 2016·Biology of Reproduction·Violeta StojanovskaTorsten Plösch
Nov 4, 2005·Biology of Reproduction·Michael C Henson, V Daniel Castracane
Oct 31, 2008·The Journal of Obstetrics and Gynaecology Research·Julie Bienertová-VaskůVít Unzeitig
Oct 23, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Toby MansellUNKNOWN Barwon Infant Study Investigator Team
Sep 15, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rebecca TroisiRobert N Hoover
May 1, 2021·International Journal of Molecular Sciences·Victoria E de KnegtUlrik Lausten-Thomsen
Mar 13, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Ana C PaleiFrank T Spradley

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