Umbilical cord serum PBDE concentrations and child adiposity measures at 7 years

Ecotoxicology and Environmental Safety
Jianqiu GuoZhijun Zhou

Abstract

Polybrominated diphenyl ethers (PBDEs) exist extensively in the environment. Toxicological studies suggested PBDEs may interfere with adipogenic pathways. However, few human evidence addressed PBDE exposures in utero related to childhood adiposity. We assessed associations between PBDEs concentrations in cord serum and childhood adiposity measures at 7 years. Among 318 mother-child pairs from Sheyang Mini Birth Cohort Study (SMBCS) in China, nine PBDE congener concentrations were quantified in umbilical cord serum using gas chromatography-negative chemical ionization mass spectrometry (GC-NCI-MS). Anthropometric indicators of children aged 7 years were measured, including weight, height and waist circumference. Age and sex-specific body mass index (BMI) z scores were calculated based on World Health Organization (WHO)'s child growth standards. Multivariate linear and logistic regression models adjusted for putative confounders were performed to examine associations between PBDE congeners and adiposity parameters. BDE-209 was the most abundant congener of PBDEs with a median value of 19.5 ng/g lipid. The geometric mean values of nine PBDE congeners ranged from below limit of detection (LOD) to 18.1 ng/g lipid, and the detection ...Continue Reading

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Citations

Apr 6, 2021·Reproductive Toxicology·Xiaotong WangBernard Robaire
Nov 13, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Nikos StratakisVaia Lida Chatzi

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