PMID: 8962723Jan 1, 1996Paper

Umbilical cord transforming growth factor-beta 3: isolation, comparison with recombinant TGF-beta 3 and cellular localization

Growth Factors
A A StewartK K Iwata

Abstract

The transforming growth factor beta (TGF-beta) family of growth modulators play critical roles in tissue development and maintenance. Recent data suggest that individual TGF-beta isoforms (TGF-beta 1, -beta 2 and -beta 3) have overlapping yet distinct biological actions and target cell specificities, both in developing and adult tissues. The TGF-beta 3 isoform was purified to homogeneity from both natural and recombinant sources and characterized by laser desorption mass spectrometry, by protein sequencing, by amino acid analysis and by biological activity. TGF-beta 3 was the major TGF-beta isoform in umbilical cord (230 ng/g), and was physically and biologically indistinguishable from recombinant TGF-beta 3 and from the tumor growth inhibitory (TGI) protein found in umbilical cord. Immunohistochemistry using antipeptide TGF-beta 3 specific antibody showed TGF-beta 3 localization in perivascular smooth muscle.

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Citations

Jan 16, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alexander StoffDavid T Curiel
Nov 17, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S E ReznikL D Fricker
Aug 21, 2014·Journal of Immunotoxicology·Fabian Caja, Luca Vannucci
Oct 18, 2005·Placenta·K SobolewskiS Jaworski

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