PMID: 109414May 1, 1979

Umbilical vein as ureteral replacement

Investigative Urology
K F Klippel, R Hohenfellner

Abstract

In 13 dogs the middle one-third of the ureter and in four dogs the entire ureter was replaced by fresh Rhesus monkey or human umbilical cord vein. The overall success rate was 60 per cent (10/17); one dog revealed an excellent intravenous pyelogram; the typical roentgenographic appearance of the kidney was a slight hydronephrosis. Animals surviving for more than 1 year were nephrectomized on the contralateral side. One dog is still alive at 36 months. Histologically, the typical structures of the umbilical vein remained unchanged after 2 years, but endothelium was replaced by urothelium. The umbilical vein seems to be an embryonic tissue of extremely low antigenicity and therefore suitable for transplantation.

Related Concepts

Anthropoidea
Glutaraldehyde-Stabilized Grafts
Canis familiaris
Melting
Graft Rejection
Hydronephrosis
Macaca mulatta
Transplantation, Autologous
Xenograft Procedure
Umbilical Vein

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.