PMID: 15225137Jul 1, 2004Paper

Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression

The Journal of Endocrinology
G LiP J Scarpace

Abstract

The effects of the chronic activation of the central melanocortin (MC) system by melanotan II (MTII) were assessed in chow-fed (CH) and high-fat (HF) diet-induced obese (DIO) Sprague-Dawley rats. Six-day central infusion of MTII (1 nmol/day) reduced body weight and visceral adiposity compared with ad libitum-fed control and pair-fed groups and markedly suppressed caloric intake in both CH and DIO rats. The anorexic response to MTII was similar in DIO relative to CH rats. MTII induced a sustained increase in oxygen consumption in DIO but a delayed response in CH rats. In both diet groups, MTII reduced serum insulin and cholesterol levels compared with controls. HF feeding increased brown adipose tissue (BAT) uncoupling protein 1 (UCP1) by over twofold, and UCP1 levels were further elevated in MTII-treated CH and DIO rats. MTII lowered acetyl-CoA carboxylase expression and prevented the reduction in muscle-type carnitine palmitoyltransferase I mRNA by pair-feeding in the muscle of DIO rats. Compared with CH controls, hypothalamic MC3 and MC4 receptor expression levels were reduced in DIO controls. This study has demonstrated that, despite reduced hypothalamic MC3/MC4 receptor expression, anorexic and thermogenic responses to MTII...Continue Reading

Citations

Nov 30, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C J StockerJ R S Arch
Sep 22, 2007·The Journal of Clinical Investigation·Ruben NogueirasMatthias H Tschöp
May 14, 2011·The Journal of Endocrinology·Lourdes M AndinoPhilip J Scarpace
Nov 10, 2013·The Journal of Endocrinology·Keld FosgerauBirgitte S Wulff
Jul 6, 2011·Neurobiology of Disease·Hyae-Ran ByunJae-Young Koh
Apr 13, 2010·Neuropeptides·E PéterváriM Balaskó
Jun 20, 2006·Physiology & Behavior·Yi Zhang, Philip J Scarpace
Jun 28, 2005·Peptides·Wei FanShaun F Morrison
Jun 25, 2016·British Journal of Pharmacology·Jocelyn M BischofRachel Wevrick
Dec 20, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Sheila CostfordMary-Ellen Harper
Aug 30, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yubin ZhangThomas W Gettys
Mar 29, 2007·American Journal of Physiology. Endocrinology and Metabolism·Gang LiPhilip J Scarpace
Nov 5, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tobias Fromme, Martin Klingenspor
Nov 14, 2017·Canadian Journal of Physiology and Pharmacology·Isabelle CôtéPhilip J Scarpace
Nov 6, 2010·Endocrine Reviews·Floor Remmers, Henriette A Delemarre-van de Waal
Jun 4, 2005·Endocrinology·Randy J SeeleyRussell J Sheldon
Jun 29, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barry E Levin
Nov 18, 2005·Peptides·Joanne A Harrold, Gareth Williams

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.