PMID: 16507416Mar 2, 2006Paper

Unargued issues on the pathological assessment of response in primary systemic therapy for breast cancer

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Katsumasa KuroiFutoshi Akiyama

Abstract

The role of primary systemic therapy (PST) in the treatment of operable breast cancer is currently under intensive investigation in the hope of allowing greater conservation of the breast, and emerging evidence suggests that induction of a pathological complete response (pCR) is at least, to some extent, predictive of long-term clinical response. In this review, we highlight the issues of pathologic evaluation after PST. We performed a computer-assisted MEDLINE search, and additional references were found in the bibliographies of these articles. So far, several grading classifications are used to assess pathologic responses after PST, and pCR rates vary from 1% to 54.7% according to the PST regimens employed. However, the term "pCR" has not been applied in a consistent, standardized manner, and the pCR rates appear to depend not only on the differences in the definition of pCR, but also on the extent of tissue sampling and the techniques used for pathologic examination. So far, only limited information is available about the reliability and validity of the definition of pathologic responses. Assessment of pCR needs to be standardized, and each grading system should be verified for reliability and validity. As a lack of standard...Continue Reading

References

Feb 17, 2001·Breast Cancer : the Journal of the Japanese Breast Cancer Society·M KurosumiUNKNOWN Commitee for Production of Histopathological Criteria, Japanese Breast Cancer Society
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ian C SmithKeith N Ogston
Aug 28, 2002·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Seigo NakamuraKoyu Suzuki
Dec 17, 2002·Critical Reviews in Oncology/hematology·Catherine Shannon, Ian Smith
Jun 28, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Manfred KaufmannHans-Jörg Senn

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Citations

Sep 24, 2010·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hitoshi TsudaTakayuki Kinoshita
Mar 16, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shinji OhnoMasakazu Toi
Mar 28, 2009·Annals of Surgical Oncology·John C Mansour, Roderich E Schwarz
Mar 7, 2006·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Katsumasa KuroiFutoshi Akiyama
Sep 6, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W Fraser SymmansLajos Pusztai
Dec 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeon-Hor ChenMin-Ying Su
Jul 27, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David A Cameron
Feb 28, 2014·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Katsumasa KuroiFutoshi Akiyama

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