Unbalanced chromosomal rearrangements in a metastasizing salivary gland tumor with benign histology

Cancer Genetics and Cytogenetics
Y JinF Mertens

Abstract

Benign metastasizing pleomorphic adenoma (BMPA) is a rare tumor of the salivary glands. Despite benign histopathologic features, it can metastasize and is sometimes lethal. No chromosomal data have been reported for this tumor type. We have by chromosome banding and fluorescence in situ hybridization analysis examined the short-term cultures of three skeletal metastases from a BMPA and identified two related hypodiploid clones: 44,XX,dic(3;22)(p11;q13) or der(3)t(3;22)(p11;q?) add(22)(q?),der(9;21)(q10;q10),der(13)t(1;13)(q11;p13)/45,XX,-3,der(9;21 ) (q10;q10),der(13)t(1;13)(q11; p13),?der(22)t(3;22)(q22;q13), +mar. The karyotypic features of this BMPA thus differ from the characteristic cytogenetic findings in pleomorphic adenomas and carcinomas ex pleomorphic adenoma.

References

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Citations

Jul 8, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Karolin H HallorFredrik Mertens
Jan 21, 2015·Histopathology·Fernanda Viviane MarianoAlbina Altemani
Feb 5, 2008·Asian Cardiovascular & Thoracic Annals·Ko Yung SitShui Wah Chiu
Mar 12, 2005·Current Opinion in Otolaryngology & Head and Neck Surgery·Patrick J Bradley
May 17, 2019·The American Journal of Surgical Pathology·Jason K WassermanIlan Weinreb
May 27, 2017·Head and Neck Pathology·Rana AlshagroudAlfredo Aguirre
Sep 16, 2008·Archives of Pathology & Laboratory Medicine·Varsha Manucha, Olga B Ioffe

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