Unbalanced Sphingolipid Metabolism and Its Implications for the Pathogenesis of Psoriasis

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Katarzyna Bocheńska, Magdalena Gabig-Cimińska

Abstract

Sphingolipids (SLs), which have structural and biological responsibilities in the human epidermis, are importantly involved in the maintenance of the skin barrier and regulate cellular processes, such as the proliferation, differentiation and apoptosis of keratinocytes (KCs). As many dermatologic diseases, including psoriasis (PsO), intricately characterized by perturbations in these cellular processes, are associated with altered composition and unbalanced metabolism of epidermal SLs, more education to precisely determine the role of SLs, especially in the pathogenesis of skin disorders, is needed. PsO is caused by a complex interplay between skin barrier disruption, immune dysregulation, host genetics and environmental triggers. The contribution of particular cellular compartments and organelles in SL metabolism, a process related to dysfunction of lysosomes in PsO, seems to have a significant impact on lysosomal signalling linked to a modulation of the immune-mediated inflammation accompanying this dermatosis and is not fully understood. It is also worth noting that a prominent skin disorder, such as PsO, has diminished levels of the main epidermal SL ceramide (Cer), reflecting altered SL metabolism, that may contribute not ...Continue Reading

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Citations

Nov 26, 2020·Chinese Medical Journal·Ni LianMin Chen
Feb 10, 2021·Chemistry and Physics of Lipids·Sophie Knox, Niamh M O'Boyle
Jul 16, 2021·Cell Biochemistry and Biophysics·E BerdyshevE Goleva

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Methods Mentioned

BETA
histone acetylation
SMase

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