PMID: 9160848Apr 1, 1997Paper

Unbiased cocaine conditioned place preferences (CPP) obscures conditioned locomotion, and nimodipine blockade of cocaine CPP is due to conditioned place aversions

Psychopharmacology
M T Martin-IversonS Sharma

Abstract

The effect of nimodipine (0, 0.1, 1.0 and 10 mg/kg, SC), a dihydropyridine L-type Ca2+ channel antagonist, on the establishment of cocaine-(10 mg/kg IP) conditioned place preferences (CPP) was investigated. Nimodipine produced conditioned place aversions (CPA) on its own; reductions in cocaine CPP are apparently due to this CPA. There is a high negative correlation between time spent in the CS+ compartment and the difference in locomotion rates between the CS+ and the non-drug (CS-) compartments, independent of drug effects. This relationship is responsible for an increased rate of locomotion observed in the CS- compartment in cocaine-conditioned rats. Analysis of covariance indicated that cocaine CPP occurred independently of cocaine's effects on locomotion. Furthermore, cocaine produces an increase in the rate of locomotion in the CS+ compartment when time spent in this compartment is equated with time spent in the CS- compartment. This suggests that cocaine's effects on CPP and "conditioned" locomotion are due to separate mechanisms of action. On the other hand, nimodipine-induced place aversions and locomotor rates are not independent of each other, indicating a common mechanism of action, or that one is a consequence of th...Continue Reading

Citations

May 13, 2008·Psychopharmacology·Katharine M SeipJoan I Morrell
Dec 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gregory D BusseAnthony L Riley
Jan 5, 1999·European Journal of Pharmacology·I SukhotinaA Bespalov
Jan 31, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Twum-Ampofo AnsahDolores C Shockley
Dec 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gregory D Busse, Anthony L Riley
Oct 28, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giovanni AddoloratoAntonello Bonci
Oct 5, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Francesco CasamassimaRoy H Perlis
Mar 30, 2010·Neurotoxicology and Teratology·Sherry A Ferguson, Sherin Y Boctor

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