Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal

Gastroenterology
J FletcherK E McColl

Abstract

Gastroesophageal reflux typically occurs after meals. During dual gastric and esophageal pH monitoring, we observed that postprandial refluxate was often more acidic than the gastric contents. This study aimed to investigate this phenomenon. Dual gastric and esophageal pH tracings were analyzed from 40 dyspeptic patients. Dual pH electrode pull-through studies were performed in healthy volunteers to document regional variation in intragastric pH under both fasting and postprandial conditions. The squamocolumnar junction was identified using radio-opaque endoscopic clips. We also examined in vitro partitioning of gastric juice added to a homogenized fatty meal. The dual pH traces confirmed that esophageal refluxate was frequently more acidic than the body of the stomach after meals but not during fasting. The pull-through studies showed a pocket of acid at the gastroesophageal junction that escaped the buffering effect of meals, remaining highly acidic (median pH 1.6) compared with the body of the stomach (pH 4.7; P < 0.001). This proximal acid pocket extended from the cardia across the squamocolumnar junction 1.8 cm into the distal esophagus. The in vitro studies showed that acidic gastric juice could partition on top of a homo...Continue Reading

References

Nov 1, 1976·The American Journal of Digestive Diseases·O T NebelD O Castell
Aug 1, 1991·Gastroenterology·R ShakerW J Hogan
Dec 16, 1982·The New England Journal of Medicine·W J DoddsM S Egide
Nov 1, 1995·Gastroenterology·A J CameronH A Carpenter
Oct 1, 1995·Scandinavian Journal of Gastroenterology·E F VerdúD Armstrong
Mar 1, 1997·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P BoulbyR C Spiller

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Citations

Feb 4, 2003·Alimentary Pharmacology & Therapeutics·P ZentilinV Savarino
Jul 3, 2004·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A MeiningW Heldwein
Aug 19, 2004·European Journal of Gastroenterology & Hepatology·Daniel Sifrim
Nov 24, 2004·The American Journal of Gastroenterology·Daniel Sifrim, Xin Zhang
Mar 25, 2006·Alimentary Pharmacology & Therapeutics·G N Tytgat, G Simoneau
May 26, 2006·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J E PandolfinoP J Kahrilas
Aug 19, 2006·Journal of Clinical Gastroenterology·Amine HilaDonald O Castell
Mar 14, 2007·Scandinavian Journal of Gastroenterology·Mark Van BlankensteinPeter Bytzer
Nov 2, 2007·Alimentary Pharmacology & Therapeutics·G N TytgatH K Batchelor
Aug 23, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sudip K GhoshJames G Brasseur
Jun 27, 2008·Journal of Magnetic Resonance Imaging : JMRI·Reto TreierPeter Boesiger
Apr 7, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·O GoetzeW Schwizer
May 14, 2009·The American Journal of Gastroenterology·Roy K H Wong, Sean F Altekruse
Nov 17, 2009·World Journal of Gastroenterology : WJG·Mei-Ju ChenFung-Chang Sung
Jun 3, 2010·Nature Reviews. Gastroenterology & Hepatology·Rami J Badreddine, Kenneth K Wang
Jan 18, 2011·Journal of Pediatric Gastroenterology and Nutrition·Hayat M MousaSamuel Nurko
Jul 6, 2011·Alimentary Pharmacology & Therapeutics·K RaviD A Katzka
Dec 17, 2011·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·F A M HerbellaM G Patti
Feb 1, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M KusanoM Akuzawa
Jun 12, 2014·United European Gastroenterology Journal·Serhat BorRukiye Vardar
Jan 15, 2015·Postgraduate Medical Journal·Guy BoeckxstaensPeter J Kahrilas
Sep 2, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·R VardarS Bor
Nov 17, 2017·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Katsuhiko Iwakiri
Apr 20, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G E Boeckxstaens
Aug 27, 2005·Scandinavian Journal of Gastroenterology·Jörgen WennerStefan Oberg
Feb 18, 2006·Scandinavian Journal of Gastroenterology·Olle AnderssonRuth Magnus
Oct 13, 2006·Current Opinion in Gastroenterology·Daniel Sifrim, Frank Zerbib
Mar 25, 2006·Alimentary Pharmacology & Therapeutics·P MalfertheinerN A Wright
Jun 5, 2007·Current Opinion in Gastroenterology·George Karamanolis, Daniel Sifrim
Jun 30, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T HershcoviciR Fass
Sep 23, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F A M HerbellaM G Patti
Dec 5, 2012·Scandinavian Journal of Gastroenterology·Yeong Yeh LeeKenneth E L McColl
May 29, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J M CastorR A Shimpi
Nov 30, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C LootsM van Wijk
Oct 16, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F A M HerbellaM G Patti
Dec 21, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·T P LiellF Fornari

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