Uncertainties in IMRT dosimetry

Medical Physics
Jin Sheng LiChang-Ming Ma

Abstract

The purpose of this study is to investigate some characteristics of the beam delivery system and their effects on the dose distribution of intensity-modulated radiation therapy (IMRT) and the results of patient-specific IMRT quality assurance (QA). These characteristics include the accelerator source distribution and multileaf collimator (MLC) geometry. Monte Carlo dose calculations based on intensity maps that were built from the actual deliverable IMRT leaf sequences with and without considering the characteristics of the beam delivery system were performed in this study using in-house Monte Carlo software. The effect of the resolution of the intensity maps on the dose distribution was investigated first. The mean dose of the treatment target and the voxel doses in the high dose region of seven IMRT plans generated by different treatment planning systems for Varian 21EX and Siemens Primus linear accelerators were used for comparison and evaluation. The results show that a 0.2 x 0.2 mm2 or smaller pixel size is needed for the intensity maps for accurate IMRT dose calculation. The extrafocal source, MLC leaf thickness, leakage, tongue-and-groove structure, and the effective leaf offset can affect the mean dose by up to 1.5%, 4....Continue Reading

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Citations

Feb 4, 2012·Australasian Physical & Engineering Sciences in Medicine·S A YoganathanShaleen Kumar
Nov 28, 2012·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Mauro TambascoJ Eduardo Villarreal-Barajas
Aug 24, 2012·Journal of Radiation Research·Naoki HayashiHideki Kato
Jul 5, 2013·Medical Physics·Heming ZhenWolfgang A Tomé
Oct 14, 2011·Medical Physics·Marcel NautaMauro Tambasco
Oct 4, 2011·Physics in Medicine and Biology·Yuanyuan Ge, Bruce A Faddegon
Jul 29, 2015·Journal of Applied Clinical Medical Physics·Weiguang Yao, Jonathan B Farr
Dec 14, 2018·Physics in Medicine and Biology·Victor HernandezJordi Saez

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