Uncertainty in contextual and kinematic cues jointly modulates motor resonance in primary motor cortex

Journal of Neurophysiology
Andreea Loredana CretuNicole Wenderoth

Abstract

Contextual information accompanying others' actions modulates "motor resonance", i.e., neural activity within motor areas that is elicited by movement observation. One possibility is that we weigh and combine such information in a Bayesian manner according to their relative uncertainty. Therefore, contextual information becomes particularly useful when others' actions are difficult to discriminate. It is unclear, however, whether this uncertainty modulates the neural activity in primary motor cortex (M1) during movement observation. Here, we applied single-pulse transcranial magnetic stimulation (TMS) while subjects watched different grasping actions. We operationalized motor resonance as grip-specific modulation of corticomotor excitability measured in the index (FDI) versus the little finger abductor (ADM). We experimentally modulated either the availability of kinematic information ( experiment 1) or the reliability of contextual cues ( experiment 2). Our results indicate that even in the absence of movement kinematics, reliable contextual information is enough to trigger significant muscle-specific corticomotor excitability changes in M1, which are strongest when both kinematics and contextual information are available. The...Continue Reading

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Citations

Apr 9, 2020·Experimental Brain Research·Andreea Loredana CretuNicole Wenderoth
Nov 5, 2019·Frontiers in Human Neuroscience·Lucia Amoruso, Alessandra Finisguerra
Mar 30, 2021·Neuropsychologia·Guy RensVonne van Polanen
Jul 24, 2021·Cerebral Cortex·Sonia BettiCosimo Urgesi

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