Unchanged basal ganglia N-acetylaspartate and glutamate in idiopathic Parkinson's disease measured by proton magnetic resonance spectroscopy

Movement Disorders : Official Journal of the Movement Disorder Society
C E ClarkeA Horsman

Abstract

The lentiform nucleus of five patients with idiopathic Parkinson's disease (IPD) was studied by quantitative magnetic resonance spectroscopy (MRS), both before and after administration of apomorphine, and the spectra were compared with those from a group of age-matched normal subjects. The concentrations of the three major metabolites, choline, creatine, and N-acetylaspartate (NAA), were quantified using tissue water content as an internal concentration reference. Glutamate concentration was assessed as the (glutamate + glutamine; GLX)/creatine peak area ratio. In normal subjects, the mean +/- SD concentrations of the the three metabolites were 2.4 +/- 0.4 mumol/g wet wt for choline, 11.5 +/- 0.8 mumol/g for creatine, and 14.7 +/- 2.8 mumol/g for NAA. The Glx/creatine ratio was 1.26 +/- 0.12. There was no significant difference in these parameters in the lentiform nucleus of patients with IPD either before or after apomorphine. The absence of detectable differences in IPD in this study implies that the changes in glutamate metabolism in the basal ganglia predicted by animal work are more subtle than those currently observable by MRS.

References

Jan 1, 1991·Movement Disorders : Official Journal of the Movement Disorder Society·J M BrotchieA R Crossman
Jan 1, 1991·Movement Disorders : Official Journal of the Movement Disorder Society·T Z AzizA R Crossman
Jan 1, 1990·Movement Disorders : Official Journal of the Movement Disorder Society·A FerbertH Brückmann
Jan 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmR Sauter
Aug 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H K LeeO Nalcioglu
Sep 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W Dreher, D Leibfritz
May 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B A HolshouserH Masur
Feb 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·G K WenningN P Quinn
Nov 1, 1995·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·G StilwellJ L Sherman

❮ Previous
Next ❯

Citations

Jul 12, 2002·Journal of Magnetic Resonance Imaging : JMRI·David AxelsonJan Aasly
Feb 6, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·C Davie
Feb 7, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·W R Wayne Martin
Oct 3, 2003·European Journal of Pharmacology·Ryota TaguchiAkinori Akaike
Jun 14, 2000·European Journal of Pharmacology·F MurrayS Grimwood
Feb 15, 2001·European Journal of Pharmacology·D MaimoneL M Grimaldi
Jul 23, 1999·Progress in Neurobiology·F Bordi, A Ugolini
May 24, 2000·Progress in Neurobiology·F BlandiniE Martignoni
Sep 7, 2000·Brain Research Bulletin·K AbeT Yanagihara
Jul 27, 2001·Journal of Chemical Neuroanatomy·Y SmithA I Levey
Oct 20, 1998·Progress in Retinal and Eye Research·C RomanoJ W Olney
Jun 1, 2002·Parkinsonism & Related Disorders·J Jankovic, C Hunter
Jan 3, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C E Clarke, M Lowry
Apr 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C A GuevaraG J Barker
Sep 21, 2001·Journal of Geriatric Psychiatry and Neurology·Y Y HsuM W Weiner
Oct 11, 2014·BioMed Research International·Rosella CiurleoSilvia Marino
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C E Clarke, M Lowry
Mar 6, 2007·NMR in Biomedicine·Nils KicklerPierre Pollak
Aug 28, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Claudio LucettiUbaldo Bonuccelli
Oct 2, 2007·NMR in Biomedicine·H Randall GriffithJan A den Hollander
Sep 25, 2002·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hyun-Man BaikJae-Mun Lee
Feb 17, 2000·Current Opinion in Neurology·B G Jenkins, E Kraft
Dec 12, 2012·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Bonnie E LevinAaron Mittel
Jan 13, 2019·Molecular Neurodegeneration·Yaping Shao, Weidong Le

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.