Unclassified Renal Cell Carcinoma With Medullary Phenotype Versus Renal Medullary Carcinoma: Lessons From Diagnosis in an Italian Man Found to Harbor Sickle Cell Trait

Urology Case Reports
Piergiuseppe ColomboMahul B Amin

Abstract

Medullary carcinoma is a rare malignant tumor of the kidney. It affects individuals of African descent and all cases reported show evidence of sickle cell trait. We reviewed an unusual carcinoma arising in a white man, the ninth in the literature. The tumor demonstrated features associated with renal medullary carcinoma, or unclassified renal cell carcinoma, medullary phenotype as recently described; the presence of sickle cell trait confirmed the diagnosis of medullary carcinoma. This case is helpful in the differential diagnosis with non-sickle cell associated "renal cell carcinoma, unclassified with medullary phenotype," and study of this spectrum of tumors is ongoing.

References

Jan 1, 1995·The American Journal of Surgical Pathology·C J DavisI A Sesterhenn
Feb 4, 2012·The American Journal of Surgical Pathology·Priya RaoPheroze Tamboli

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Citations

Feb 17, 2017·Case Reports in Oncology·Madhumati R KalavarSaroj Davi Kunnakkat
Jan 19, 2019·Current Urology Reports·Leandro BlasFederico Cicora
Aug 16, 2017·Journal for Immunotherapy of Cancer·Quaovi SodjiJigarkumar Parikh
Jul 12, 2017·Journal of Oncology Practice·Kathryn E BeckermannW Kimryn Rathmell

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Methods Mentioned

BETA
biopsy

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