Uncommon responses of segmental vitiligo to melanocyte-keratinocyte transplantation procedure

Journal of Cutaneous Medicine and Surgery
Prescilia IsedehSanjeev V Mulekar

Abstract

Patients with segmental vitiligo (SV), unlike those with nonsegmental vitiligo (NSV), have a more predictable course and are more responsive to surgery. To report 10 patients with SV treated with the melanocyte-keratinocyte transplantation procedure (MKTP), who responded with unusual responses not previously reported in the literature. This is a retrospective, observational study that reports 10 patients with SV who underwent the MKTP between May 2003 and May 2012. Two patients had successful repigmentation after split-thickness skin grafting after failure of the MKTP. Two patients developed a hypopigmented ring at a margin of the MKTP-treated area. One patient had complete repigmentation after a second MKTP. Two patients developed koebnerization of the recipient site. Three patients developed new vitiligo patches in previously unaffected areas after the MKTP. Uncommon and even suboptimal responses can occur following the MKTP in SV patients. There is a need for studies to provide better understanding and outcomes for SV patients undergoing the MKTP.

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Citations

Feb 22, 2018·Plastic and Reconstructive Surgery. Global Open·Bonnie C CarneyJeffrey W Shupp
Jun 4, 2016·Plastic and Reconstructive Surgery. Global Open·Giulio GualdiPiergiacomo Calzavara-Pinton
Jul 10, 2020·The Journal of Dermatological Treatment·Thanyanan SritanyaratNarumol Silpa-Archa

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