Uncommon Trimethoxylated Flavonol Obtained from Rubus rosaefolius Leaves and Its Antiproliferative Activity

Evidence-based Complementary and Alternative Medicine : ECAM
Marcel PetreanuRivaldo Niero

Abstract

This study shows the evaluation the antiproliferative effect of the extract, fractions, and uncommon compounds isolated from R. rosaefolius leaves. The compounds were identified by conventional spectroscopic methods such as NMR-H(1) and C(13) and identified as 5,7-dihydroxy-6,8,4'-trimethoxyflavonol (1), 5-hydroxy-3,6,7,8,4'-pentamethoxyflavone (2), and tormentic acid (3). Both hexane and dichloromethane fractions showed selectivity for multidrug-resistant ovary cancer cell line (NCI-ADR/RES) with total growth inhibition values of 11.1 and 12.6 μg/ml, respectively. Compound 1 also showed selective activity against the same cell line (18.8 μg/ml); however, it was especially effective against glioma cells (2.8 μg/ml), suggesting that this compound may be involved with the in vitro antiproliferative action.

References

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Citations

Jun 23, 2020·Journal of Toxicology and Environmental Health. Part a·Ana Paula Oliveira De QuadrosEdson Luis Maistro
Apr 27, 2019·The Journal of Pharmacy and Pharmacology·Artur ManukyanMichael Heinrich

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Methods Mentioned

BETA
NMR
column chromatography

Software Mentioned

ORIGIN
NIST08

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