Unconventional transcriptional response to environmental enrichment in a mouse model of Rett syndrome.

PloS One
Bredford KerrJuan I Young

Abstract

Rett syndrome (RTT) is an X-linked postnatal neurodevelopmental disorder caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2) and one of the leading causes of mental retardation in females. RTT is characterized by psychomotor retardation, purposeless hand movements, autistic-like behavior and abnormal gait. We studied the effects of environmental enrichment (EE) on the phenotypic manifestations of a RTT mouse model that lacks MeCP2 (Mecp2(-/y)). We found that EE delayed and attenuated some neurological alterations presented by Mecp2(-/y) mice and prevented the development of motor discoordination and anxiety-related abnormalities. To define the molecular correlate of this beneficial effect of EE, we analyzed the expression of several synaptic marker genes whose expression is increased by EE in several mouse models. We found that EE induced downregulation of several synaptic markers, suggesting that the partial prevention of RTT-associated phenotypes is achieved through a non-conventional transcriptional program.

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Citations

Sep 26, 2013·Epigenomics·Takeo KubotaTakae Hirasawa
Mar 13, 2014·Neuromolecular Medicine·Vichithra R B Liyanage, Mojgan Rastegar
Jun 7, 2014·Expert Review of Molecular Diagnostics·Takeo KubotaKazuki Mochizuki
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Feb 19, 2015·Developmental Medicine and Child Neurology·Bernard DanGuy Cheron
May 28, 2014·Journal of the Peripheral Nervous System : JPNS·Alleene V StricklandStephan Züchner
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Jun 20, 2020·ILAR Journal·Kathleen R Pritchett-Corning
Oct 11, 2016·Neural Plasticity·Eyal AronoffMichael Leon
Sep 7, 2019·Clinical Medicine Insights. Pediatrics·Wendy DrobnykStephen B Soumerai
Jul 1, 2017·Frontiers in Molecular Neuroscience·Rodrigo F TorresBredford Kerr
Jan 29, 2021·International Journal of Molecular Sciences·Monireh MansouriMaryam Ardalan

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Methods Mentioned

BETA
transgenic

Software Mentioned

- Gene 6000 Series
Rotor

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