Uncorrelated changes of subunit stability can generate length-dependent disassembly of treadmilling filaments

Physical Biology
C Erlenkämper, K Kruse

Abstract

Unregulated polymer assembly typically leads to exponential length distributions. In living cells, though, the length distribution of cytoskeletal filaments often shows a sharp maximum at a finite value. We discuss a simple mechanism for length regulation that is based on generating an effectively length-dependent disassembly rate by locally acting cytoskeletal proteins. We analyze steady-state distributions by stochastic simulations and develop a method to analytically characterize the typical filament length. We find three different types of behavior: (1) unbounded filament growth, (2) exponential distributions and (3) unimodal distributions, which can be very sharp with a standard deviation much smaller than the mean filament length. We discuss possible implications of our results for subcellular processes.

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Citations

Feb 26, 2014·Journal of Nanobiotechnology·Karsten Kruse
Nov 5, 2013·The Journal of Chemical Physics·C Erlenkämper, K Kruse
Feb 16, 2011·Biophysical Journal·Maximilian Ebbinghaus, Ludger Santen
Jun 25, 2015·PLoS Computational Biology·Lishibanya MohapatraJane Kondev
May 6, 2016·Annual Review of Biophysics·Lishibanya MohapatraJane Kondev
Oct 3, 2018·Proceedings of the National Academy of Sciences of the United States of America·Shishen DuJoe Lutkenhaus
Apr 20, 2019·Physical Review. E·Atul Kumar VermaArvind Kumar Gupta
Sep 26, 2012·Physical Review Letters·Anna MelbingerErwin Frey
Dec 12, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Christoph ErlenkämperKarsten Kruse
Sep 26, 2012·Physical Review Letters·Denis JohannKarsten Kruse
Jul 13, 2013·The Journal of Physical Chemistry. B·Xin Li, Anatoly B Kolomeisky
Feb 28, 2014·The Journal of Physical Chemistry. B·Xin Li, Anatoly B Kolomeisky

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