PMID: 8938263Feb 9, 1996Paper

Uncoupling between cortical glucose metabolism and blood flow after ibotenate lesion of the rat basal forebrain: a PET study

Neuroscience Letters
M OgawaH Tsukada

Abstract

We evaluated the cerebral metabolic rate of glucose (CMRGlu) and cerebral blood flow (CBF) after unilateral lesioning of the rat basal forebrain cholinergic projection system using ibotenic acid. Using positron emission tomography, we measured CMRGlu and CBF with [18F]-2-fluoro-2-deoxy-D-glucose (FDG) and with H2(15)O, respectively. Three days after surgery, CMRGlu and k3* (the rate constant for the phosphorylation of FDG) were reduced in the frontal cortex on the ibotenic acid-injected side, whereas CBF and K1* (the rate constant for the FDG transport from the plasma to brain) in the same rats remained in the normal range. It is concluded that the decreased cortical CMRGlu after the lesion of the cholinergic system projecting from the basal forebrain is due to the diminished neural activity rather than to decreased CBF.

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Citations

Oct 12, 2001·Current Opinion in Neurobiology·R E Jacobs, S R Cherry
Dec 22, 1998·Epilepsia·C BruehlO W Witte
Jun 29, 2011·Progress in Neurobiology·Paul BentleyRaymond J Dolan
Jun 19, 2004·Reviews in the Neurosciences·Susanne NikolausRolf Larisch

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Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.