Abstract
Differentiation generally leads to cell cycle arrest. Human leukemia HL60 cells respond to the presence of 1,25-dihydroxyvitamin D3 (1,25D3) by expressing a number of markers of the monocyte/macrophage phenotype and become arrested predominantly in the G1 phase of the cell cycle. We have recently reported a series (A) of 1,25D3-resistant variants of HL60 cells which proliferate in the presence of 1,25D3 and do not express differentiation markers (Exp. Cell Res. 224, 312, 1996). We now describe another series (B) of such variants, which differ from A series cells grown in similar concentrations of 1,25D3 in that they express the CD14 antigen and nonspecific esterase, characteristic of the monocyte, while continuing to proliferate and they develop hypotetraploid DNA (4C) content at higher concentrations of ambient 1,25D3 than the A series cells. Cells in the B series with 4C DNA content (100B and 200B) also differed from the A series 4C cells by the absence of DNA binding by the full-length Sp1 transcription factor. However, B series cells resembled the A series cells in exhibiting faster growth rates than the parental HL60 cells and showed high levels of vitamin D receptor and retinoid receptor X proteins. These results show tha...Continue Reading
References
Aug 1, 1979·The Journal of Cell Biology·P E NewburgerH J Cohen
Nov 24, 1977·Nature·S J CollinsR E Gallagher
May 25, 1979·Science·G RoveraL Diamond
Jan 30, 1992·Nature·S A KliewerR M Evans
Nov 1, 1992·Experimental Cell Research·H M XuG P Studzinski
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·X P YuS C Manolagas
Sep 21, 1990·Science·S D WrightJ C Mathison
Mar 1, 1991·Cell Proliferation·P PanG P Studzinski
May 26, 1991·The New England Journal of Medicine·R P WarrellA Jakubowski
May 1, 1990·Molecular and Cellular Biology·S J CollinsL Mueller
May 17, 1990·Nature·D J MangelsdorfR M Evans
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J LiaoJ W Pike
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M StromH F DeLuca
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A R BakerB W O'Malley
Dec 24, 1987·Cell·J T KadonagaR Tjian
Jun 1, 1986·The Journal of Cell Biology·Z S Brelvi, G P Studzinski
Mar 1, 1971·American Journal of Clinical Pathology·L T YamW H Crosby
Feb 15, 1980·International Journal of Cancer. Journal International Du Cancer·S J CollinsR C Gallo
Nov 30, 1983·Biochemical and Biophysical Research Communications·H TanakaT Suda
Jan 1, 1983·Leukemia Research·D M McCarthyJ M Goldman
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T R BreitmanS J Collins
Oct 1, 1981·The Journal of Clinical Investigation·J D GriffinS F Schlossman
May 1, 1996·Experimental Cell Research·H J WajchmannG P Studzinski
Jul 1, 1996·Journal of Cellular Physiology·F ZhangG P Studzinski
Jan 1, 1994·Cell Proliferation·J J GodynG P Studzinski
Apr 1, 1984·Immunology Today·D T Fearon
Citations
May 12, 2011·The Journal of Biological Chemistry·Romina GutschKorbinian Brand
Dec 6, 2012·Leukemia Research and Treatment·Elżbieta GocekEwa Marcinkowska
Aug 13, 2008·Endocrine Reviews·Roger BouillonMarie Demay
Aug 5, 2015·Journal of Clinical Medicine·Elzbieta Gocek, George P Studzinski
Sep 4, 2010·Cell Biology International·Peng JiangQin Wang
Aug 5, 2009·Critical Reviews in Clinical Laboratory Sciences·Elzbieta Gocek, George P Studzinski
Apr 3, 1998·Journal of Cellular Physiology·J RaoG P Studzinski
Aug 14, 2001·Journal of Cellular Biochemistry·C M HansenL Binderup
Feb 3, 2004·Journal of Cellular Physiology·Xuening Wang, George P Studzinski
Jun 16, 2001·Journal of Cellular Biochemistry·X Wang, G P Studzinski
Nov 5, 1997·Journal of Cellular Biochemistry·T W ReichmanG P Studzinski
May 10, 2007·Cancer·Wunchana SeubwaiSopit Wongkham
Jan 1, 1997·Pathology Oncology Research : POR·Rudolf MihalikLászló Kopper
Feb 13, 2001·Journal of Cellular Biochemistry·X Wang, G P Studzinski
Jun 18, 2002·Journal of Cellular Physiology·Yan JiGeorge P Studzinski
Mar 29, 2000·Journal of Cellular Physiology·Q M WangL E Harrison
Mar 6, 2003·Journal of Cancer Research and Clinical Oncology·István MolnárGary G Schwartz
Oct 10, 2001·Cell Proliferation·J W ChoM H Suh
Jan 20, 2004·Cancer Research·Yan Ji, George P Studzinski
Mar 31, 2000·Experimental Cell Research·C W LinY C Tse-Dinh
Jun 15, 1999·Experimental Cell Research·F Chen, G P Studzinski