Uncoupling of GABA(A) and benzodiazepine receptor binding activity in the hippocampal formation of schizophrenic brain

Brain Research
Francine M BenesMark S Todtenkopf

Abstract

A recent postmortem study has reported that there is a widespread upregulation of GABA(A) receptor binding activity throughout most subregions of the hippocampal formation of schizophrenic brain. The current study has been undertaken to determine whether the benzodiazepine (BZ) receptor, which is a component of the GABA(A) receptor complex, may also be upregulated in schizophrenics. Using a low-resolution film autoradiographic technique to localize [3H]flunitrazepam binding, the subregional and laminar distribution of specific BZ receptor binding was found to parallel that of the GABA(A) site, except in the area dentata where BZ binding was approximately 73% higher in the outer molecular layer. When BZ receptor binding was compared in the same normal control (n = 15) and schizophrenic (n = 8) cases in which the GABA(A) receptor was analyzed, there were very few differences noted between the two groups, except for small, though significant, increases in the stratum oriens of CA3 (30%), the subiculum (20-30%) and the presubiculum (15-20%) of the patient group. These latter increases overlapped with the subregions and laminae in schizophrenics showing the most marked increases of GABA(A) receptor binding. Using a high-resolution t...Continue Reading

Citations

May 2, 1998·The Australian and New Zealand Journal of Psychiatry·B D GyntherP Sah
Jul 27, 2000·Annals of the New York Academy of Sciences·F M Benes, S Berretta
Oct 10, 2007·Harvard Review of Psychiatry·W Gordon Frankle
Sep 4, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francine M Benes
Apr 5, 2007·Nature Protocols·Sabina Berretta, Francine M Benes
Dec 20, 2005·Experimental Brain Research·Chao Deng, Xu-Feng Huang
Jun 7, 2017·Translational Psychiatry·A EgertonP McGuire
Oct 6, 2007·Molecular Neurobiology·Gerhard Rammes, Rainer Rupprecht
Oct 8, 2004·Schizophrenia Research·Sarah M Clinton, James H Meador-Woodruff

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