PMID: 9442982Jan 1, 1997Paper

Uncoupling of serotonergic and noradrenergic systems in depression: preliminary evidence from continuous cerebrospinal fluid sampling

Depression and Anxiety
T D GeraciotiM H Ebert

Abstract

We used the technique of continuous cerebrospinal fluid (CSF) sampling to test the following hypotheses regarding CNS monoaminergic systems in depression: (1) absolute concentrations of the informational substances tryptophan and 5-hydroxyindoleacetic acid (5-HIAA) are altered in the CNS of depressed patients (2) abnormal rhythms of tryptophan and/or 5-HIAA, or defective conversion of tryptophan to serotonin (5HT), exist in the CNS of depressed patients, and (3) the relationship between the CNS 5HT and norepinephrine (NE) systems is disrupted in depressed patients. We obtained 6-h concentration time series of tryptophan, 5-HIAA, NE, and 3-methoxy-4-hydroxyphenylglycol (MHPG) in the CSF of 10 patients with major depression and in 10 normal volunteers. No significant differences in CSF tryptophan, 5-HIAA, NE, or MHPG concentrations or rhythms were observed between normal volunteers and depressed patients. Neither were there differences in the mean tryptophan-to-serotonin ratio. However, a negative linear relationship was observed between mean concentrations of 5-HIAA and NE in the CSF of the normal volunteers (r = 0.916 [r2 = 0.839], df = 9, P < 0.001) while, in contrast, depressed patients showed no such relationship (r = +0.094...Continue Reading

Citations

May 28, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Mats B LindströmLil Träskman-Bendz
Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, Louis D Van de Kar
Dec 15, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·K Koed, K Linnet
Feb 24, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Karin Stiasny-KolsterGeorg F Hoffmann
Nov 24, 1999·Biological Psychiatry·K J Ressler, C B Nemeroff

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