Uncoupling ribosome biogenesis regulation from RNA polymerase I activity during herpes simplex virus type 1 infection.

RNA
Stéphane BelinJean-Jacques Diaz

Abstract

The ribosome is the central effector of protein synthesis, and its synthesis is intimately coordinated with that of proteins. At present, the most documented way to modulate ribosome biogenesis involves control of rDNA transcription by RNA polymerase I (RNA Pol I). Here we show that after infection of human cells with herpes simplex virus type 1 (HSV-1) the rate of ribosome biogenesis is modulated independently of RNA Pol I activity by a dramatic change in the rRNA maturation pathway. This process permits control of the ribosome biogenesis rate, giving the possibility of escaping ribosomal stress and eventually allowing assembly of specialized kinds of ribosomes.

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Citations

May 13, 2015·Virology·Gabriel Ouellet Lavallée, Angela Pearson
Jan 1, 2014·Biochimica Et Biophysica Acta·Anna Salvetti, Anna Greco
Apr 15, 2015·Biochimie·Guokai Yan, Xianghua Yan
Oct 23, 2010·Molecular Cell·Séverine BoulonAngus I Lamond
Dec 3, 2014·PloS One·Claudia L KleinmanAlessandro Michienzi
Apr 27, 2010·Biochimica Et Biophysica Acta·Sjoerd Wanrooij, Maria Falkenberg
Sep 29, 2019·PLoS Neglected Tropical Diseases·Martin SelingerLibor Grubhoffer
Dec 15, 2010·Current Protocols in Cell Biology·Stéphane BelinJean-Jacques Diaz
Dec 11, 2017·Biochemistry. Biokhimii︠a︡·J A FilippovaG A Stepanov

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